Corpus callosum neuromodulation method

• US 8,942,812 B2
• Filed: 04/05/2013
• Issued: 01/27/2015
• Est. Priority Date: 05/04/2004
• Status: Active Grant

• Current Assignee: Cleveland Clinic Foundation
• Original Assignee: Cleveland Clinic Foundation
• Inventors: Machado, Andre, Rezai, Ali R.
• Primary Examiner(s): Schaetzle, Kennedy
• Application Number:
  US13/857,815
• Publication Number:
  US 20130238068A1
• Time in Patent Office: 662 Days
• Field of Search: None
• US Class Current: 607/45
• CPC Class Codes: A61N 1/0531 Brain cortex electrodes
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/0539 Anchoring of brain electrode systems, e.g. within burr hole
• CPC Class Codes: A61N 1/3605 Implantable neurostimulators for stimulating central or peripheral nerve system
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease

Abstract

Neuromodulation assemblies with lead bodies having curvatures that mimic the curvatures of the splenium, trunk, genu, or rostrum of the corpus callosum. Methods of stimulating the corpus callosum and methods of securing an electrical lead in the brain are also provided.

Claims

1. A method of stimulating a corpus callosum, the method comprising:

placing an electrical lead having an electrode disposed thereon in communication with a corpus callosum; and

activating the electrode to apply an electrical signal to the corpus callosum to stimulate the corpus callosum;

wherein at least one of;

the electrode comprises a plurality of electrodes arranged at different axial positions along a length of the electrical lead; and

the electrical lead is cylindrical.

2. The method of claim 1, wherein the electrode comprises the plurality of electrodes arranged at the different axial positions along the length of the electrical lead.

3. The method of claim 1, wherein the electrical lead penetrates the corpus callosum.

4. The method of claim 3, wherein the electrical lead is cylindrical.

5. A method of stimulating a corpus callosum, the method comprising:

placing an electrical lead, with an electrode disposed thereon, in communication with a corpus callosum, wherein the electrical lead is delivered to the corpus callosum intravascularly; and

activating the electrode to apply an electrical signal to the corpus callosum to stimulate the corpus callosum.

6. A method of stimulating a corpus callosum, the method comprising:

placing an electrical lead, with an electrode disposed thereon, in communication with, and on an under-surface of, a corpus callosum; and

activating the electrode to apply an electrical signal to the corpus callosum to stimulate the corpus callosum.

7. A method of stimulating a corpus callosum, the method comprising:

placing an electrical lead having an electrode disposed thereon in communication with a corpus callosum; and

activating the electrode to apply an electrical signal to the corpus callosum to stimulate the corpus callosum;

wherein at least one of;

(A) the electrical lead penetrates the corpus callosum and at least one of;

(i) the method further comprises anchoring the electrical lead to the dura mater of the brain; and

(ii) the electrical lead extends within the corpus callosum approximately along a longitudinal axis of the corpus callosum;

(B) the electrical lead includes a lead body and at least one of;

(i) the lead body is of flexible material that is deformable from a pre-operative shape to a different post-operative shape; and

(ii) the electrical lead further comprises a conductor that extends approximately perpendicularly away from the lead;

(C) the placement of the electrical lead is such that the bottom surface thereof faces and extends longitudinally along the corpus callosum and the top surface thereof, that is opposite the bottom surface, faces away from the corpus callosum, the top surface being insulated without any electrode being exposed at the top surface; and

(D) the method further comprises anchoring the electrical lead via at least one anchor, and at least one of;

(i) the electrode comprises a plurality of electrodes;

(ii) the electrical lead penetrates the corpus callosum; and

(iii) the electrical lead is cylindrical.

8. The method of claim 7, wherein the electrical lead penetrates the corpus callosum and the method comprises the anchoring of the electrical lead to the dura mater of the brain.

9. The method of claim 8, wherein the dura mater is the dura mater of the convexity.

10. The method of claim 8, wherein the dura mater is the falx.

11. The method of claim 7, wherein the electrical lead includes the lead body of flexible material that is deformable from the pre-operative shape to the different post-operative shape.

12. The method of claim 11, wherein the lead body includes at least one fastener, and the placing of the electrical lead includes inserting the electrical lead using a tool fastened to the lead body via the at least one fastener.

13. The method of claim 11, wherein:

the placing of the electrical lead includes inserting the lead body into the brain while the electrical lead is in a folded position; and

the lead body is unfolded when it is positioned at the corpus callosum.

14. The method of claim 13, wherein the insertion of the lead body in the folded position is through a cannula, the lead body being unfolded upon exit from the cannula.

15. The method of claim 13, wherein the placing of the electrical lead is performed using a tool attached to the lead body, the tool initially holding the lead body in the folded position, and the tool being used to spread the lead body open into the unfolded position when the lead body is at the corpus callosum.

16. The method of claim 7, wherein:

the method comprises the anchoring of the electrical lead via the at least one anchor; and

at least one of;

(i) the electrode comprises the plurality of electrodes;

(ii) the electrical lead penetrates the corpus callosum; and

(iii) the electrical lead is cylindrical.

17. The method of claim 16, wherein the electrical lead includes a lead body and a conductor extending from the lead body, and the at least one anchor is disposed on the conductor.

18. The method of claim 16, wherein the electrical lead includes a lead body, a conductor, and an accessory strand, and the at least one anchor is disposed on the accessory strand.

19. The method of claim 16, wherein the at least one anchor is slidably connected to the electrical lead.

20. The method of claim 7, wherein the electrical lead comprises the lead body and the conductor that extends approximately perpendicularly away from the lead.

21. The method of claim 20, wherein the conductor is coupled to approximately a center of the lead body.

22. The method of claim 7, wherein the placement of the electrical lead is such that the bottom surface thereof faces and extends longitudinally along the corpus callosum and the top surface thereof, that is opposite the bottom surface, faces away from the corpus callosum, the top surface being insulated without any electrode being exposed at the top surface.

23. The method of claim 22, wherein the electrode comprises the plurality of electrodes exposed at the bottom surface.

24. The method of claim 22, wherein the extension of the top and bottom surfaces is in a direction approximately along a longitudinal axis of the corpus callosum.

25. The method of claim 7, wherein the electrical lead penetrates the corpus callosum and extends within the corpus callosum approximately along a longitudinal axis of the corpus callosum.