Application of american ginseng to enhance neurocognitive function

• US 8,968,800 B2
• Filed: 11/03/2011
• Issued: 03/03/2015
• Est. Priority Date: 05/04/2009
• Status: Active Grant

• Current Assignee: Naturex SA (Givaudan SA)
• Original Assignee: Naturex SA (Givaudan SA)
• Inventors: Ibarra, Alvin, Dikansky, Jacques, Scholey, Andrew, He, Kan, Roller, Marc
• Primary Examiner(s): HOFFMAN, SUSAN COE
• Application Number:
  US13/288,745
• Publication Number:
  US 20120046239A1
• Time in Patent Office: 1,216 Days
• Field of Search: 424/728
• US Class Current: 424/728
• CPC Class Codes: A61K 36/258 Panax (ginseng)
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

Disclosed are methods of enhancing neurocognitive function by administering of American Ginseng. Preferred dosages in the range of 5 to 50 mg total genosides enhance cognitive function—including, improvement of working memory (WM) performance, attentional performance (e.g., Choice Reaction Time accuracy), and calmness.

Claims

1. A method of enhancing cognitive performance in working memory of a human subject in need thereof, the method comprising administering to said human subject a composition comprising American ginseng extract and a carrier, in an effective amount to enhance the cognitive performance, wherein said American ginseng extract comprises 3 parts of ginsenoside Rb2;

3 parts of ginsenoside Rg1;

22 parts of ginsenoside Re;

61 parts of ginsenoside Rb1;

20 parts of ginsenoside Rc and 16 parts of ginsenoside Rd; and

said ginsenoside Rb2, said ginsenoside Rg1, said ginsenoside Re, said ginsenoside Rb1, said ginsenoside Rc, and said ginsenoside Rd constitute 11.65% of the weight of said American ginseng extract.

2. The method of claim 1 wherein said American ginseng extract is free of ginsenoside Rf.

3. The method of claim 1 wherein the effective amount comprises about 23.30 mg of said ginsenoside Rb2, said ginsenoside Rg1, said ginsenoside Re, said ginsenoside Rb1, said ginsenoside Rc, and said ginsenoside Rd in total.

4. The method of claim 1, wherein the method further comprises assessing said cognitive performance by administering Numeric Working Memory test to said human subject.

5. The method of claim 4 wherein said human subject is administered said composition between 1 and 6 hours prior to the step of assessing said cognitive performance.

6. The method of claim 1, wherein the carrier is maltodextrin.

7. A method of enhancing cognitive performance in numeric working memory within 6 hours after an administration of American ginseng extract, the method comprising administering about 200 mg of American ginseng extract to a human subject in need of enhancing cognitive performance in numeric working memory within 6 hours after an administration of American ginseng extract, wherein said American ginseng extract comprises about 0.2% of ginsenoside Rb2;

about 0.2% of ginsenoside Rg1;

about 2.0% of ginsenoside Re;

about 5.0% of ginsenoside Rb1;

about 2.0% of ginsenoside Rc and about 1.4% of ginsenoside Rd.

8. The method of claim 7 wherein said American ginseng extract is free of ginsenoside Rf.

9. The method of claim 7, wherein the method further comprises assessing said cognitive performance by administering Numeric Working Memory test to said human subject.

10. The method of claim 9, wherein said American ginseng extract comprises about 23.30 mg of said ginsenoside Rb2, said ginsenoside Rg1, said ginsenoside Re, said ginsenoside Rb1, said ginsenoside Rc, and said ginsenoside Rd in total;

and wherein said human subject is administered said American ginseng extract between 1 and 6 hours prior to the step of assessing said cognitive performance.