Medical implant

• US 9,278,016 B2
• Filed: 02/22/2011
• Issued: 03/08/2016
• Est. Priority Date: 05/20/2009
• Status: Active Grant

• Current Assignee: Lyra Therapeutics, Inc.
• Original Assignee: 480 Biomedical, Inc.
• Inventors: Busold, Rany, Core, Lee, Ho, Kicherl, Palasis, Maria, Sharma, Upma, You, Changcheng, Concagh, Daniel, Zugates, Greg
• Primary Examiner(s): STEWART, ALVIN J
• Application Number:
  US13/032,281
• Publication Number:
  US 20110238162A1
• Time in Patent Office: 1,841 Days
• Field of Search: 623/1.15, 623/1.19, 623/1.2, 623 138- 146
• US Class Current: 1/1
• CPC Class Codes: A61F 2/86 Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2/90 characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2/95 Instruments specially adapted for placement or removal of stents or stent-grafts
• CPC Class Codes: A61F 2/9522 Means for mounting a stent or stent-graft onto or into a placement instrument
• CPC Class Codes: A61F 2230/0054 V-shaped
• CPC Class Codes: A61L 31/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/14 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence
• CPC Class Codes: D04C 1/06 Braid or lace serving particular purposes
• CPC Class Codes: D10B 2403/0112 One smooth surface, e.g. laminated or coated
• CPC Class Codes: D10B 2509/06 Vascular grafts; stents

Abstract

Disclosed is a self-expanding medical implant for placement within a lumen of a patient. The implant comprises a woven or non-woven structure having a substantially tubular configuration, and is designed to be low-profile such that it is deliverable with a small diameter catheter. The implant has a high recoverability and desired mechanical properties.

Claims

1. An implantable medical device, comprising:

a self-expanding tubular structure comprising

at least one strand comprising a first biodegradable material; and

a second biodegradable material at least partially conformally coating said strand;

wherein said tubular structure comprises a first diameter greater than 2.5 mm, and said tubular structure recovers to at least 90% of said first diameter after being crimped to a diameter that is less than 50% of said first diameter,

wherein said first diameter is a manufactured diameter of said tubular structure.

2. The implantable medical device of claim 1, wherein said first biodegradable material comprises poly(lactic acid co-glycolic acid).

3. The implantable medical device of claim 2, wherein said poly(lactic acid co-glycolic acid) comprises at least about 75 weight percent of lactic acid.

4. The implantable medical device of claim 2, wherein said poly(lactic acid co-glycolic acid) comprises about 85 weight percent of lactic acid.

5. The implantable medical device of claim 2, wherein said poly(lactic acid co-glycolic acid) comprises up to about 20 weight percent of lactic acid.

6. The implantable medical device of claim 1, wherein said second biodegradable material is a random copolymer that is crosslinked.

7. The implantable medical device of claim 1, wherein said second biodegradable material is selected from the group consisting of poly(lactic acid-co-caprolactone), poly(glycolide-co-caprolactone, poly trimethylene carbonate, and poly(lactic acid-co-dioxanone).

8. The implantable medical device of claim 7, wherein said second biodegradable material is poly(lactic acid-co-caprolactone) comprising about 50 to 70 weight percent lactic acid.

9. The implantable medical device of claim 8, wherein said poly(lactic acid-co-caprolactone) is crosslinked with hexamethylene diisocyanate.

10. The implantable medical device of claim 1, further comprising a therapeutic agent within at least one of said first biodegradable material and said second biodegradable material.

11. An implantable medical device, comprising:

a self-expanding tubular structure comprising

at least one strand comprising a first biodegradable polymer; and

a second biodegradable polymer conformally coating said strand, said second polymer being a thermoset copolymer;

wherein said tubular structure;

comprises a first diameter greater than 4.5 mm;

recovers to at least 90% of said first diameter after being crimped to a to a diameter that is less than 50% of said first diameter, and

exerts a force against a blood vessel wall immediately after being implanted in said blood vessel, wherein said force decreases over time,

and wherein said first diameter is a manufactured diameter of said tubular structure.

12. The implantable medical device of claim 11, wherein said first diameter is at least about 6.0 mm.

13. The implantable medical device of claim 11, wherein said first diameter is at least about 7.0 mm.

14. An implantable medical device, comprising:

a self-expanding tubular structure comprising

at least one strand comprising a first biodegradable material; and

a second biodegradable material at least partially conformally coating said strand;

wherein said tubular structure comprises a first diameter greater than 2.5 mm, and said tubular structure recovers to at least 90% of said first diameter after being crimped to a diameter that is less than 70% of said first diameter,

wherein said first diameter is a manufactured diameter of said tubular structure.

15. The implantable medical device of claim 14, wherein said first diameter is at least about 6.0 mm.

16. An implantable medical device, comprising:

a self-expanding tubular structure comprising

at least one strand comprising a first biodegradable polymer; and

a second biodegradable polymer conformally coating said strand, said second polymer being a thermoset copolymer;

wherein said tubular structure;

comprises a first diameter greater than 4.5 mm;

recovers to at least 90% of said first diameter after being crimped to a to a diameter that is less than 70% of said first diameter, and

exerts a force against a blood vessel wall immediately after being implanted in said blood vessel, wherein said force decreases over time,

and wherein said first diameter is a manufactured diameter of said tubular structure.