Systems and methods enabling high-throughput, real time detection of analytes
First Claim
1. A system for detecting an analyte comprising:
- a plasmonic interferometer, the plasmonic interferometer comprising a first surface and a second surface on an opposite side of the plasmonic interferometer than the first surface, the first surface having a first groove and a second groove and a slit disposed between the first groove and the second groove to define a first distance between the slit and the first groove and a second distance between the slit and the second groove, wherein the first and second distances are selected to provide interference of light at the slit;
a light source for illuminating the first surface of the plasmonic interferometer;
a detector for detecting light transmitted through the slit, the detector positioned proximate to the second surface of the plasmonic interferometer; and
a sample holder for disposing a sample to be analyzed onto the first surface of the plasmonic interferometer.
1 Assignment
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Accused Products
Abstract
System and methods for detecting analytes are provided. The system includes a plasmonic interferometer with a first surface having a first and second scattering element and an aperture disposed between the first scattering element and the second scattering element. A first distance between the aperture and the first scattering element and a second distance between the aperture and the second scattering element are selected to provide interference of light at the slit. The system also includes a light source for illuminating the first surface of the plasmonic interferometer, a detector positioned for detecting light transmitted through the aperture, and a sample holder for disposing a sample to be analyzed onto the first surface of the plasmonic interferometer.
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Citations
42 Claims
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1. A system for detecting an analyte comprising:
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a plasmonic interferometer, the plasmonic interferometer comprising a first surface and a second surface on an opposite side of the plasmonic interferometer than the first surface, the first surface having a first groove and a second groove and a slit disposed between the first groove and the second groove to define a first distance between the slit and the first groove and a second distance between the slit and the second groove, wherein the first and second distances are selected to provide interference of light at the slit; a light source for illuminating the first surface of the plasmonic interferometer; a detector for detecting light transmitted through the slit, the detector positioned proximate to the second surface of the plasmonic interferometer; and a sample holder for disposing a sample to be analyzed onto the first surface of the plasmonic interferometer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35)
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36. A system for detecting a plurality of analytes comprising:
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a plurality of plasmonic interferometers, each plasmonic interferometer comprising; a first surface and a second surface on an opposite side of the plasmonic interferometer than the first surface, the first surface having a first groove and a second groove; and a slit disposed between the first groove and the second groove to define a first distance between the slit and the first groove and a second distance between the slit and the second groove; wherein the first and second distances are selected to provide controlled interference of light at the aperture slit; a light source for illuminating the first surface of each of the plurality of plasmonic interferometers; a plurality of detectors for detecting light transmitted through the slit of each plasmonic interferometer, each detector positioned proximate to the second surface of a corresponding plasmonic interferometer; and a plurality of sample holders, each sample holder disposing a sample to be analyzed onto the first surface of each plasmonic interferometer. - View Dependent Claims (37, 38, 39, 40, 41)
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42. A system for detecting an analyte comprising:
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a plasmonic interferometer, the plasmonic interferometer comprising a first surface and a second surface on an opposite side of the plasmonic interferometer than the first surface, the first surface having a first groove and a second groove and a slit disposed between the first groove and the second groove to define a first distance between the slit and the first groove and a second distance between the slit and the second groove, wherein the first and second distances are selected to provide interference of light at the slit; a light source for illuminating the first surface of the plasmonic interferometer; a detector for detecting light transmitted through the slit, the detector positioned proximate to the second surface of the plasmonic interferometer; and a sample holder for disposing a sample to be analyzed onto the first surface of the plasmonic interferometer; wherein the sample comprises an oxidative or chromogenic dye selected to absorb particular light frequencies.
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Specification