Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists, and formulations thereof
First Claim
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1. A composition comprising:
- a thyroid hormone analog conjugated to a polymer, wherein conjugation to the polymer results in a particle with a diameter which does not allow the thyroid hormone analog conjugated to the polymer to cross a nucleus membrane and limits thyroid hormone analog activity to only a cell surface receptor wherein upon administration, the conjugated thyroid hormone analog binds to a cell surface receptor integrin α
vβ
3;
a morphogenic protein; and
a bioresorbable carrier.
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Abstract
Disclosed are methods of treating subjects having conditions related to angiogenesis including administering an effective amount of a polymeric Nanoparticle form of thyroid hormone agonist, partial agonist or an antagonist thereof, to promote or inhibit angiogenesis in the subject. Compositions of the polymeric forms of thyroid hormone, or thyroid hormone analogs, are also disclosed.
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Citations
19 Claims
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1. A composition comprising:
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a thyroid hormone analog conjugated to a polymer, wherein conjugation to the polymer results in a particle with a diameter which does not allow the thyroid hormone analog conjugated to the polymer to cross a nucleus membrane and limits thyroid hormone analog activity to only a cell surface receptor wherein upon administration, the conjugated thyroid hormone analog binds to a cell surface receptor integrin α
vβ
3;a morphogenic protein; and a bioresorbable carrier. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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Specification