Antimicrobial-coated medical articles
First Claim
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1. An article comprising:
- a coating composition comprising a vinyl polymer having a plurality of pendant groups comprisinga first pendant group comprising a cationic component selected from the group consisting of a quaternary amine component, protonated tertiary amine component, and a protonated secondary amine component;
a second pendant group comprising a nonpolar component wherein the second pendant group is selected from the group consisting of linear or branched alkanes, alkaryl, aralkyl, aromatic groups, and combinations thereof; and
a third pendant groupa third pendant group comprising a first organosilicon component;
wherein the vinyl polymer does not comprise a pendant group that comprises a carboxylate group; and
a medical device comprising an elastomeric first substrate having a patient-contact first surface and a second surface;
wherein the vinyl polymer is durably adhered to the patient-contact first surface, wherein the composition is free of inorganic filler; and
wherein the coating composition was deposited and cured with an additional free silane present in the coating composition;
wherein the additional free silane is a quaternary ammonium silane or protonated tertiary amino silane having at least one straight or branched chain alkyl of 6-22 carbon atoms.
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Abstract
The disclosure provides polymers having antimicrobial activity and articles with the polymers coated thereon. The polymers include a first pendant group comprising a first cationic component, a second pendant group comprising a nonpolar component, and a third pendant group comprising an organosilane component. The disclosure also includes methods of coating medical device articles and body fluid-receiving substrates with the antimicrobial polymers. The methods further include the use of adhesion-promoting components.
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Citations
18 Claims
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1. An article comprising:
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a coating composition comprising a vinyl polymer having a plurality of pendant groups comprising a first pendant group comprising a cationic component selected from the group consisting of a quaternary amine component, protonated tertiary amine component, and a protonated secondary amine component; a second pendant group comprising a nonpolar component wherein the second pendant group is selected from the group consisting of linear or branched alkanes, alkaryl, aralkyl, aromatic groups, and combinations thereof; and
a third pendant groupa third pendant group comprising a first organosilicon component; wherein the vinyl polymer does not comprise a pendant group that comprises a carboxylate group; and a medical device comprising an elastomeric first substrate having a patient-contact first surface and a second surface; wherein the vinyl polymer is durably adhered to the patient-contact first surface, wherein the composition is free of inorganic filler; and wherein the coating composition was deposited and cured with an additional free silane present in the coating composition;
wherein the additional free silane is a quaternary ammonium silane or protonated tertiary amino silane having at least one straight or branched chain alkyl of 6-22 carbon atoms. - View Dependent Claims (2, 3, 4, 5, 6, 7, 17, 18)
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8. An article comprising:
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a coating composition comprising a vinyl polymer having a plurality of pendant groups comprising a first pendant group comprising a cationic component selected from the group consisting of a quaternary amine component, protonated tertiary amine component, and a protonated secondary amine component; a second pendant group comprising a nonpolar component wherein the second pendant group is selected from the group consisting of linear or branched alkanes, alkaryl, aralkyl, aromatic groups, and combinations thereof; and a third pendant group comprising a first organosilicon component; wherein the vinyl polymer does not comprise a pendant group that comprises a carboxylate group; and an elastomeric body fluid-contacting first substrate having a body fluid-contacting first surface and a second surface; wherein the vinyl polymer is durably adhered to the body fluid-contacting first surface, and wherein the composition is free of inorganic filler. - View Dependent Claims (9, 10, 11, 12, 13, 14)
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15. A method of making a coated article, the method comprising:
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forming a first coating composition comprising a vinyl polymer having a plurality of pendant groups comprising a first pendant group comprising a first cationic component selected from the group consisting of a quaternary amine component, protonated tertiary amine component, and a protonated secondary amine component; a second pendant group comprising a nonpolar component wherein the second pendant group is selected from the group consisting of linear or branched alkanes, alkaryl, aralkyl, aromatic groups, and combinations thereof; and a third pendant group comprising a first organosilicon component; wherein the vinyl polymer does not comprise a pendant group that comprises a carboxylate group; and wherein the first coating composition is free of inorganic filler; and contacting the first coating composition with a first surface of a first substrate to adhere the vinyl polymer to the first surface; wherein the first substrate comprises an elastomeric component of a medical device or an elastomeric body fluid-contacting substrate.
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16. A medical device article comprising a coating wherein the coating is derived from:
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a composition comprising a free silane component and a vinyl polymer having a plurality of pendant groups comprising a first pendant group comprising a first quaternary ammonium component; a second pendant group comprising a nonpolar component wherein the second pendant group is selected from the group consisting of linear or branched alkanes, alkaryl, aralkyl, aromatic groups, and combinations thereof; and a third pendant group comprising a first organosilicon component; wherein the vinyl polymer does not comprise a pendant group that comprises a carboxylate group; wherein the vinyl polymer is durably adhered to a surface of the article; and wherein the composition is free of inorganic filler.
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Specification