Methods and compositions for inhibiting CD32b expressing cells
First Claim
Patent Images
1. A protein comprising an Fc variant comprising at least amino acid modifications S267E and L328F as compared to a parent Fc polypeptide, wherein numbering is according to the EU index according to Kabat.
1 Assignment
0 Petitions
Accused Products
Abstract
The present invention relates to immunoglobulins that bind FcγRIIb+ cells and coengage the antigen on the cell'"'"'s surface and an FcγRIIb on the cell'"'"'s surface, methods for their generation, and methods for using the immunoglobulins.
75 Citations
3 Claims
- 1. A protein comprising an Fc variant comprising at least amino acid modifications S267E and L328F as compared to a parent Fc polypeptide, wherein numbering is according to the EU index according to Kabat.
-
3. A protein comprising an Fc variant comprising at least amino acid modifications S267E and L328F as compared to a parent Fc polypeptide, wherein numbering is according to the EU index according to Kabat, wherein said Fc variant has increased binding affinity to Fcγ
- RIIb as compared to the parent Fc polypeptide.
Specification