Methods and systems for chemical ablation

• US 9,907,601 B2
• Filed: 04/14/2014
• Issued: 03/06/2018
• Est. Priority Date: 11/24/2009
• Status: Active Grant

• Current Assignee: Regents of The University of Minnesota (University of Minnesota)
• Original Assignee: Regents of The University of Minnesota (University of Minnesota)
• Inventors: Cressman, Erik N. K.
• Primary Examiner(s): STIGELL, THEODORE J
• Application Number:
  US14/251,957
• Publication Number:
  US 20140221830A1
• Time in Patent Office: 1,422 Days
• CPC Class Codes: A61B 18/06 caused by chemical reaction , e.g. moxaburners
• CPC Class Codes: A61B 2018/066 one of the reactants being oxygen not from the air
• CPC Class Codes: A61B 2090/3904 specially adapted for marking specified tissue
• CPC Class Codes: A61B 2505/05 Surgical care
• CPC Class Codes: A61B 90/39 Markers, e.g. radio-opaque or breast lesions markers
• CPC Class Codes: A61M 25/007 Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked
• CPC Class Codes: A61M 39/0247 Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body peritoneal dialysis catheters A61M1/285; tracheostomy devices A61M16/0465; measuring pressure within the body A61B5/03; colostomy devices A61F5/445; gastrotomy feeding tubes A61J15/0015; means for fixing a feeding tube outside of the body A61J15/0053
• CPC Class Codes: A61M 5/007 for contrast media
• CPC Class Codes: A61M 5/162 Needle sets, i.e. connections by puncture between reservoir and tube ; Connections between reservoir and tube in jet-action syringes A61M5/30; connectors for tubes having sealed ends and a needle for piercing them A61M39/14

Abstract

Thermochemical ablation techniques may provide ablation of bodily tissue using chemical reaction energy.

Claims

1. A thermochemical ablation system, comprising:

a percutaneous fluid delivery cannula comprising first and second lumens extending from a proximal portion to a distal portion, the distal portion comprising a first side port in fluid communication with at least the first lumen and a second side port in fluid communication with at least the second lumen;

a first reservoir that contains a reducing agent so as to communicate the reducing agent through the first lumen to the distal portion of the percutaneous fluid delivery cannula, at least a portion of the reducing agent being deliverable out of the first side port, wherein the reducing agent is selected from the group consisting of glycerol, dextrin, maltodextrin, glucose, sucrose, hydrogen peroxide, iron(II) ammonium sulfate, titanium trichloride, cuprous chloride, stannous sulfate, and sodium thiosulphate; and

a second reservoir that contains an oxidizing agent so as to communicate the oxidizing agent through the second lumen to the distal portion of the percutaneous fluid delivery cannula, at least a portion of the oxidizing agent being deliverable out of the second side port to react with the reducing agent at the distal portion and generate an exothermic redox reaction.

2. The system of claim 1, wherein the redox reaction results in a change in oxidation state for the oxidizing and reducing agents.

3. The system of claim 1, wherein delivery of the reducing agent from the first side port and the oxidizing agent from the second side port provides simultaneous radial dispersion of the oxidizing and reducing agents.

4. The system of claim 3, wherein the exothermic chemical reaction generates heat to ablate bodily tissue proximate the distal portion of the percutaneous fluid delivery cannula.

5. The system of claim 1, wherein the reducing agent has a concentration of about 0.5 M to about 5 M.

6. The system of claim 1, wherein the reducing agent has a concentration of about 1 M to about 3 M.

7. The system of claim 1, wherein the oxidizing agent is selected from the group consisting of permanganate, sodium hypochlorite, sodium peroxide, iron(II) ammonium sulfate, and ammonium persulfate.

8. The system of claim 1, wherein the oxidizing agent has a concentration of about 0.5 M to about 5 M.

9. The system of claim 1, wherein the oxidizing agent has a concentration of about 1 M to about 3 M.

10. The system of claim 1, further comprising a first actuator to deliver fluid from the first reservoir and a second actuator to deliver fluid from the second reservoir, the first and second actuators being coupled to one another so as to provide simultaneous actuation.

11. The system of claim 1, wherein the percutaneous fluid delivery cannula comprises a generally rigid injection needle.

12. The system of claim 11, wherein the injection needle comprises an outside diameter of about 0.134 inches or less.

13. The system of claim 1, wherein the percutaneous fluid delivery cannula comprises a flexible catheter.

14. A method for thermochemical ablation of targeted tissue, comprising:

delivering a reducing agent through a first lumen of a percutaneous injection needle wherein the reducing agent is selected from the group consisting of glycerol, dextrin, maltodextrin, glucose, sucrose, hydrogen peroxide, iron(II) ammonium sulfate, titanium trichloride, cuprous chloride, stannous sulfate, and sodium thiosulphate;

delivering an oxidizing agent through a second lumen of the percutaneous injection needle;

simultaneously infusing the oxidizing and reducing agents into targeted tissue to mix the oxidizing and reducing agents at a distal portion of the injection needle, resulting in an exothermic redox reaction between the oxidizing and reducing agents.

15. The method of claim 14, wherein the redox reaction results in a change in oxidation state for the oxidizing and reducing agents.

16. The method of claim 14, wherein when the reducing agent is delivered from a first side port of the injection needle and the oxidizing agent is delivered from a second side port of the injection needle, the oxidizing and reducing agents are radially dispersed.

17. The method of claim 16, wherein the exothermic chemical reaction generates heat to ablate bodily tissue proximate the distal portion of the injection needle.

18. The method of claim 14, wherein the reducing agent has a concentration of about 0.5 M to about 5 M.

19. The method of claim 14, wherein the reducing agent has a concentration of about 1 M to about 3 M.

20. The method of claim 14, wherein the oxidizing agent is selected from the group consisting of permanganate, sodium hypochlorite, sodium peroxide, iron(II) ammonium sulfate, and ammonium persulfate.

21. The method of claim 14, wherein the oxidizing agent has a concentration of about 0.5 M to about 5 M.

22. The method of claim 14, wherein the oxidizing agent has a concentration of about 1 M to about 3 M.