Transdermal porator and patch system and method for using same
First Claim
Patent Images
1. A method of transdermal monitoring, comprising steps of:
- forming at least one micropore in a tissue membrane by a microporation device, while delivering a vacuum to draw the tissue membrane; and
monitoring a subcutaneous fluid via the at least one micropore by a monitoring device;
whereinthe microporation device comprising;
a vacuum source to generate the vacuum;
a disposable substratedefining a poration area andhaving an upper substrate surface, a lower substrate surface, a conduit that extends between the upper substrate surface and the lower substrate surface;
at least one channel disposed on the upper substrate surface and in fluid communication with the conduit so that the vacuum, is delivered to the poration area via the conduit and the at least one channel;
a means for forming at least one micropore in the tissue membrane, wherein said means is mounted on the substrate, and wherein at least a portion of the means is positioned within the poration area; and
wherein the vacuum acts to draw the tissue membrane into contact with the means for forming at least one micropore, when the microporation device acts to form the at least one micropore in the tissue membrane.
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Abstract
A transdermal permeant delivery of at least one permeant composition into a tissue membrane of a subject including a disposable substrate having at least a portion of a bottom surface of a first release liner connected to an upper surface of the substrate and a patch having a backing layer and a reservoir that is selectively removable from the top surface of the first release liner. In a connected position, a first portion of the backing layer of the patch is releaseably mounted to a top surface of the first release liner in spaced registration with a poration area of the substrate.
128 Citations
8 Claims
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1. A method of transdermal monitoring, comprising steps of:
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forming at least one micropore in a tissue membrane by a microporation device, while delivering a vacuum to draw the tissue membrane; and monitoring a subcutaneous fluid via the at least one micropore by a monitoring device; wherein the microporation device comprising; a vacuum source to generate the vacuum; a disposable substrate defining a poration area and having an upper substrate surface, a lower substrate surface, a conduit that extends between the upper substrate surface and the lower substrate surface; at least one channel disposed on the upper substrate surface and in fluid communication with the conduit so that the vacuum, is delivered to the poration area via the conduit and the at least one channel; a means for forming at least one micropore in the tissue membrane, wherein said means is mounted on the substrate, and wherein at least a portion of the means is positioned within the poration area; and wherein the vacuum acts to draw the tissue membrane into contact with the means for forming at least one micropore, when the microporation device acts to form the at least one micropore in the tissue membrane. - View Dependent Claims (2, 3, 4, 6, 7, 8)
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5. A transdermal monitoring system, comprising:
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a microporation device adapted to form at least one micropore in a tissue membrane, while delivering a vacuum to draw the tissue membrane; and a monitoring device adapted to monitor a subcutaneous fluid via the at least one micropore; wherein the microporation device comprising; a vacuum source to generate the vacuum; a disposable substrate defining a poration area and having an upper substrate surface, a lower substrate surface, a conduit that extends between the upper substrate surface and the lower substrate surface; at least one channel disposed on the upper substrate surface and in fluid communication with the conduit so that the vacuum is delivered to the poration area via the conduit and the at least one channel; a means for forming at least one micropore in the tissue membrane, wherein said means is mounted on the substrate, and wherein at least a portion of the means is positioned within the poration area; and wherein the vacuum acts to draw the tissue membrane into contact with the means for forming at least one micropore, when the microporation device acts to form the at least one micropore in the tissue membrane.
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Specification