Method, apparatus, and device for calculating or approximating one or more values representing parameters of a patient

• US 10,092,685 B2
• Filed: 12/09/2011
• Issued: 10/09/2018
• Est. Priority Date: 12/09/2010
• Status: Active Grant

• Current Assignee: Fresenius Medical Care Deutschland GmbH (Fresenius Medical Care AG)
• Original Assignee: Fresenius Medical Care Deutschland GmbH (Fresenius Medical Care AG)
• Inventors: Moissl, Ulrich, Wieskotten, Sebastian, Chamney, Paul, Nier, Volker, Wabel, Peter
• Primary Examiner(s): BREWSTER, HAYDEN R
• Application Number:
  US13/991,710
• Publication Number:
  US 20130277287A1
• Time in Patent Office: 2,496 Days
• Field of Search: 210 85, 210 87, 210 88, 210 961, 210 962, 210 97, 210138, 210143, 2103216, 210646, 210650, 210739, 604 65, 604 67, 702 19
• CPC Class Codes: A61M 1/16 with membranes
• CPC Class Codes: A61M 1/1613 Profiling or modelling of patient or predicted treatment evolution or outcome
• CPC Class Codes: A61M 2205/52 with memories providing a history of measured variating parameters of apparatus or patient
• CPC Class Codes: G16H 20/17 delivered via infusion or injection
• CPC Class Codes: G16H 20/40 relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
• CPC Class Codes: G16H 40/63 for local operation
• CPC Class Codes: G16H 50/20 for computer-aided diagnosis, e.g. based on medical expert systems
• CPC Class Codes: G16H 50/50 for simulation or modelling of medical disorders

Abstract

A method for calculating or estimating or approximating one or more values representing parameters of a patient includes the step of interpolating or extrapolating of at least one later value of a first parameter taking into account at least one earlier value of the first parameter, at least one earlier and at least one later value of a second parameter, and a mathematical relation between the first and the second parameter. An apparatus, a blood treatment device, a digital storage device, a computer program product, and a computer program are also described.

Claims

1. A method of operating a blood treatment device for performing a blood treatment on a patient'"'"'s blood, the method comprising:

interpolating or extrapolating, by an interpolation or extrapolation device, at least one subsequent value of a first parameter indicative of an overhydration, a relative overhydration, or a normohydrated weight of the patient, taking into account;

at least one earlier value of the first parameter obtained from a bioimpedance measurement device or from an external database during or before an earlier treatment session,

at least one earlier value of a second parameter indicative of a preweight, a haemoglobin concentration in blood, or an extracellular water content and obtained from a bioimpedance measurement device or from an external database during or before the earlier treatment session,

at least one subsequent value of the second parameter obtained after the at least one earlier value of the second parameter is obtained and before the treatment is performed, and

a mathematical relation between the at least one earlier value of the first parameter, the at least one earlier value of the second parameter, and the at least one subsequent value of the second parameter; and

performing, by the blood treatment device, the treatment in accordance to or based on the at least one interpolated or extrapolated subsequent value of the first parameter, the treatment comprising at least one of a dialysis treatment, a hemofiltration treatment, an ultrafiltration treatment, or a hemodialysis treatment.

2. The method according to claim 1, further comprising minimizing a mathematical error of the interpolating or extrapolating.

3. The method according to claim 1, further comprising minimizing a square error of the interpolating or extrapolating.

4. The method according to claim 1, further comprising weighting one or more of the earlier values.

5. The method according to claim 1, further comprising weighting values or mean values derived from earlier values of one or more parameters.

6. The method according to claim 1, further comprising using a mathematical filter, a regression analysis or neuronal networks.

7. The method according to claim 1, further comprising using a linear filter, a non-linear filter, a Kalman filter, an unscented Kalman filter, a Kalman-Bucy filter, a hybrid Kalman filter or an extended Kalman filter.

8. The method according to claim 1, further comprising using a filter that works partly or completely recursively.

9. An apparatus comprising a controller programmed to execute instructions to perform the steps of the method according to claim 1.

10. The apparatus according to claim 9, further comprising an output device for outputting results provided by carrying out the method.

11. The apparatus according to claim 9, wherein the controller is further programmed to execute instructions to control a device for treating a patient'"'"'s blood in accordance with or based on the one or more values calculated or approximated or estimated by the method.

12. A blood treatment device, comprising at least one apparatus according to claim 9.

13. The device according to claim 12, wherein the controller is further programmed to execute instructions to treat a patient by means of dialysis.

14. The device according to claim 13, wherein the controller is further programmed to execute instructions to treat a patient by haemofiltration, ultrafiltration, and/or haemodialysis.

15. A non-transitory computer-readable storage medium with an executable program stored thereon, wherein the program instructs a programmable computer system so as to execute the steps of the method according to claim 1.

16. The method according to claim 1, further comprising outputting results of the method.

17. The method according to claim 1, wherein:

the treatment is a second treatment,

the at least one earlier value of the first parameter is obtained during a first treatment, and

the at least one subsequent value of the second parameter is obtained during the second treatment.

18. The method according to claim 1, wherein the at least one earlier value of the first parameter is obtained from the bioimpedance measurement device.

19. The method according to claim 1, wherein the treatment is a subsequent treatment, and the at least one earlier value of the second parameter is measured during an earlier treatment performed before the subsequent treatment.