Composition of plant extract and its pharmaceutical composition and application thereof

• US 10,537,605 B2
• Filed: 08/28/2015
• Issued: 01/21/2020
• Est. Priority Date: 08/28/2014
• Status: Active Grant

• Current Assignee: Caliway Biopharmaceuticals Co., Ltd.
• Original Assignee: Caliway Biopharmaceuticals Co., Ltd.
• Inventors: Ling, Yu-Fang
• Primary Examiner(s): Clark, Amy L
• Application Number:
  US15/025,898
• Publication Number:
  US 20170157194A1
• Time in Patent Office: 1,607 Days
• Field of Search: None
• CPC Class Codes: A61K 2121/00 Preparations for use in therapy
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/05 Phenols cannabinoids A61K31/658
• CPC Class Codes: A61K 36/82 Theaceae (Tea family), e.g. camellia
• CPC Class Codes: A61K 36/9066 Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
• CPC Class Codes: A61K 9/0019 Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: A61K 9/0053 Mouth and digestive tract, i.e. intraoral and peroral administration rectal administration A61K9/0031
• CPC Class Codes: A61K 9/0095 Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches A61K9/0007 takes precedence; eatable gels or foams A61K9/0056; oral mucosa adhesive forms A61K9/006

Abstract

Provided is a plant extract composition and a pharmaceutical composition thereof for reducing body weight and body fat, wherein the plant extract composition comprises a green tea extract and a turmeric extract respectively 30 wt % to 75 wt % and 20 wt % to 55 wt % of a total weight of the composition. In diet-induced obesity models, either obesity is induced first or simultaneously with administration, the plant extract composition and a pharmaceutical composition thereof can reduce body weight and body fat more significantly than a single plant extract or commercially available weight loss drugs.

Claims

1. A method for reducing body weight or body fat in a subject in need thereof, comprising administering to said subject an effective amount of a composition comprising a green tea extract and a turmeric extract, wherein the amount of the green tea extract:

the turmeric extract is 30 wt%-70 wt%;

55 wt% to 20 wt%, respectively, and wherein the body fat is subcutaneous fat or visceral fat.

6. The method of claim 1, wherein the composition further comprises resveratrol in an amount between 0% and 30% based upon the total weight of the composition.

7. The method of in claim 1, the composition further comprises a pharmaceutically acceptable excipient.

8. The method of claim 1, the subject is a human or an animal.

9. The method of claim 1, the composition is orally administered or administered by injection.

10. The method of claim 9, wherein the therapeutically effective amount of the composition for a human is from 1.8 mg/kg to 145 mg/kg.

11. The method of claim 9, wherein the therapeutically effective amount of the composition for a human is from 5.4mg/kg to 70 mg/kg.

2. A method for treating overweight or obesity in a subject in need thereof, comprising administering to said subject a therapeutically effective amount of a pharmaceutical composition comprising a green tea extract and a turmeric extract, and further comprising a pharmaceutically acceptable carrier, wherein the amount of the green tea extract:

the turmeric extract is 30 wt%-70 wt%;

55 wt% to 20 wt%, respectively.

3. The method of claim 2, wherein the formulation of the pharmaceutical composition is orally administered or administered by injection.

4. The method of claim 3, wherein the therapeutically effective amount of the pharmaceutical composition for a human is from 1.8 mg/kg to 145 mg/kg.

5. The method of claim 4, wherein the therapeutically effective amount of the pharmaceutical composition for a human is from 5.4 mg/kg to 70 mg/kg.

12. The method of claim 2, wherein the composition further comprises resveratrol in an amount between 0% and 30% based upon the total weight of the composition.

13. The method of claim 2, the overweight or obese subject is a human or an animal.