System and method for treating kidney diseases in diabetic and non-diabetic patients

• US 20010053381A1
• Filed: 06/15/2001
• Published: 12/20/2001
• Est. Priority Date: 06/16/2000
• Status: Active Grant

• Current Assignee: Thomas T. Aoki
• Original Assignee: Thomas T. Aoki
• Inventors: Aoki, Thomas T.
• Granted Patent: US 6,613,342 B2
• Time in Patent Office: Days
• US Class Current: 424/439
• CPC Class Codes: A61K 38/28 Insulins

Abstract

The present invention is a system and method capable of improving the entire metabolic process and through its multiplicity of effects on neurovascular reactivity, intraglomerular presure and hemodynamics, arresting the progression of overt diabetic nephropathy, improving intraglomerular hemodynamics, and thus arresting the progression of diabetic nephropathy and therefore reducing the risk of development of End Stage Renal Disease. The current system and method is for the treatment of kidney disease using insulin pulses to a patient utilizing Chronic Intermittent Intravenous Insulin Therapy to achieve the slowing, stopping or reversing of kidney disease in both diabetic and non-diabitic patient.

Claims

1. A system for treating kidney disease in diabetic and non-diabetic patients through an intravenous site administering a pulse of insulin to a patient comprising:

a) a means for determining a respiratory quotient of the patient,

b) a liquid or food containing glucose, the liquid or food containing glucose being consumed by the patient, and

c) a means for administering intravenously the pulse of insulin at a regular interval of time until the respiratory quotient is 0.90 or greater.

2. The system of

claim 1

, wherein the intravenous site further comprises a needle or catheter located in the patient'"'"'s body, hand or forearm.

3. The system of

claim 1

, wherein the liquid or food contains 60 to 100 grams of glucose.

4. The system of

claim 1

, wherein the means for administering the pulse of insulin is an intravenous infusion device.

5. The system of

claim 1

, wherein the interval of time is about six minutes.

6. The system of

claim 1

, wherein the pulse of insulin is tailored to achieve a more normal metabolic function of the kidney.

7. The system of

claim 1

, wherein the intravenous site is converted to a heparin or a saline lock when the administration of insulin pulses has temporarily ceased between treatments.

8. A method for treating kidney disease in diabetic and non-diabetic patients through an intravenous site administering a pulse of insulin to a patient comprising the steps of:

a) determining a respiratory quotient of the patient,

b) having the patient consume a liquid or food containing glucose,

c) administering intravenously the pulse of insulin at a regular interval of time until the respiratory quotient is 0.90 or greater,

d) providing the patient a rest period, and

e) repeating the steps a-d three times.

9. The method of

claim 8

, wherein the intravenous site further comprises a needle or catheter located in the patient'"'"'s body, hand or forearm.

10. The method of

claim 8

, wherein the liquid or food contains 60 to 100 grams of glucose.

11. The method of

claim 8

, wherein the pulse of insulin is administered by an intravenous infusion devise.

12. The method of

claim 8

, wherein the interval of time is about six minutes.

13. The method of

claim 8

, wherein the pulse of insulin is tailored to achieve a more normal metabolic function of the kidney.

14. The method of

claim 8

, wherein the intravenous site is converted to a heparin or a saline lock during the rest period.

15. The method of

claim 8

, wherein the rest period is one hour.

16. The method of

claim 8

, wherein said steps a-e are repeated at least once a week.

17. The method of

claim 8

, wherein said steps a-e are repeated three or more times a week.