Treatment of bioprosthetic tissues to mitigate post implantation calcification

  • US 20030125813A1
  • Filed: 01/03/2002
  • Published: 07/03/2003
  • Est. Priority Date: 01/03/2002
  • Status: Active Grant
First Claim
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1. A method for mitigating post-implantation calcification of a bioprosthetic material, said method comprising the steps of:

  • (a) heating a glutaraldehyde solution to a first temperature for a first period of time;

    (b) adjusting the temperature of the glutaraldehyde solution to a second temperature; and

    , (c) after the temperature of the glutaraldehyde solution has been adjusted to the second temperature, contacting a quantity of biological tissue that contains connective tissue protein with the glutaraldehyde solution for a second period of time.

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