Methods for overcoming organ transplant rejection
First Claim
1. A method for preventing or retarding rejection of a transplanted organ in a subject in need thereof, said method comprising delivering a rejection effective amount of light energy to the transplanted organ;
- the light energy having a wavelength in the visible to near-infrared wavelength range, wherein delivering the rejection effective amount of light energy comprises delivering a power density of light energy to the organ of at least about 0.01 mW/cm2.
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Abstract
Therapeutic methods for preventing or retarding organ transplant rejection are described, the methods including delivering to a transplanted organ a rejection effective amount of light energy, the light energy having a wavelength in the visible to near-infrared wavelength range, wherein delivering the rejection effective amount of light energy includes selecting a power density (mW/cm2) of light energy to be received at the organ. The power density is at least about 0.01 mW/cm2 and no more than about 100 mW/cm2, to be delivered to the transplanted organ after completion of the transplant procedure.
149 Citations
22 Claims
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1. A method for preventing or retarding rejection of a transplanted organ in a subject in need thereof, said method comprising delivering a rejection effective amount of light energy to the transplanted organ;
- the light energy having a wavelength in the visible to near-infrared wavelength range, wherein delivering the rejection effective amount of light energy comprises delivering a power density of light energy to the organ of at least about 0.01 mW/cm2.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
- 10. A method for preventing or retarding rejection of a transplanted organ in a subject in need thereof comprising administering to the subject an amount of an immunosuppressive agent and delivering to the transplanted organ an amount of light energy wherein the amount of the immunosuppressive agent and the amount of light energy together constitute a rejection effective amount, wherein delivering the amount of light energy comprises selecting a power density of the light energy.
- 17. A method for reducing the amount of an immunosuppressive agent or agents administered to a transplant subject to prevent or retard rejection of a transplanted organ, said method comprising delivering to the transplanted organ a rejection effective amount of light energy, the light energy having a wavelength in the visible to near-infrared wavelength range, wherein delivering the rejection effective amount of light energy comprises selecting a predetermined power density of light energy, the amount of light energy further sufficient to reduce the amount of immunosuppressive agent or agents required to prevent or retard rejection of the transplanted organ relative to the amount of immunosuppressive agent or agents required to prevent or retard rejection of the transplant organ without the use of light energy.
Specification