Induction of insulin expression
First Claim
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1. A method for inducing insulin gene expression in cells, the method comprising the steps of:
- (i) providing a cell that expresses a PDX-1 polynucleotide; and
(ii) contacting the cell with a histone deacetylase inhibitor, thereby inducing insulin gene expression in the cells.
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Abstract
The present invention provides compositions and methods for inducing insulin expression in cells by contacting the cells with a histone deacetylase inhibitor.
50 Citations
44 Claims
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1. A method for inducing insulin gene expression in cells, the method comprising the steps of:
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(i) providing a cell that expresses a PDX-1 polynucleotide; and
(ii) contacting the cell with a histone deacetylase inhibitor, thereby inducing insulin gene expression in the cells. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A method of identifying a compound that modulates β
- -cell function, the method comprising the steps of contacting a cell with a compound in the presence of a histone deactylase inhibitor, wherein the cell expresses a PDX-1 polynucleotide; and
determining the effect of the compound on β
-cell function. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
- -cell function, the method comprising the steps of contacting a cell with a compound in the presence of a histone deactylase inhibitor, wherein the cell expresses a PDX-1 polynucleotide; and
- 29. A culture of cells expressing PDX-1, wherein the culture comprises a histone deacetylase inhibitor.
Specification