Device and system for the quantification of breath gases
First Claim
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1. ) A device for quantifying an analyte in a gaseous sample, comprising:
- a sample chamber, for holding the gaseous sample;
a sensing element within said sample chamber, said sensing element capable of change in an optically-quantifiable characteristic in the presence of the analyte;
a light source for exposing said sensing element to light;
a detector, for measurement of the response of the sensing element to said light; and
a signal processor for determining concentration of the analyte from a signal produced by said detector.
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Abstract
The present invention is a device and system for the measurement of substances in exhaled breath. Its basic components include (i) an optional inlet unit to provide controlled air to the subject, (ii) an outlet unit for capturing exhaled breath from the subject, (iii) a sample chamber, (iv) a sensing element, such as a bioactive compound in a sol-gel matrix, (v) a light source, (vi) a detector, (vii) control circuitry, (viii) a signal processor, (ix) a display, and (x) optional storage means.
69 Citations
28 Claims
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1. ) A device for quantifying an analyte in a gaseous sample, comprising:
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a sample chamber, for holding the gaseous sample;
a sensing element within said sample chamber, said sensing element capable of change in an optically-quantifiable characteristic in the presence of the analyte;
a light source for exposing said sensing element to light;
a detector, for measurement of the response of the sensing element to said light; and
a signal processor for determining concentration of the analyte from a signal produced by said detector. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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25. ) A system for determining the concentration of an analyte in a sample of exhaled breath, comprising:
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a sample chamber, for holding the sample of exhaled breath;
a sensing element within said sample chamber, said sensing element capable of change in an optically-quantifiable characteristic in the presence of the analyte;
a light source for exposing said sensing element to light;
a detector, for measurement of optically-based change of the sensing element to said light; and
a signal processor for determining concentration of the analyte from a signal produced by said detector.
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26. ) A system for quantifying NO in exhaled breath, comprising:
- an outlet unit for capturing exhaled breath from a subject;
a sample chamber connected to said outlet unit, for holding the exhaled breath;
a sensing element within said sample chamber, said sensing element comprising a sol gel matrix containing cytochrome-c;
a LED for exposing said sol gel matrix to light;
a blue-enhanced photodetector for measurement of the response of the sensing element to light from said LED; and
a signal processor for determining concentration of NO in exhaled breath from a signal produced by said photodetector; and
a display in communication with said signal processor for displaying NO concentration.
- an outlet unit for capturing exhaled breath from a subject;
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27. ) A method of determining the concentration of an analyte in a gaseous sample, comprising:
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providing a sensing element, said sensing element capable of change in an optically-quantifiable characteristic change in the presence of the analyte;
exposing said sensing element to exhaled breath;
determining the degree of optically-based change in the sensing element as a result of its exposure to the exhaled breath; and
correlating the degree of optically-based change to concentration of the analyte. - View Dependent Claims (28)
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Specification