Kinase inhibitors

• US 20040019067A1
• Filed: 10/22/2002
• Published: 01/29/2004
• Est. Priority Date: 01/22/1999
• Status: Abandoned Application

• Current Assignee: Amgen Inc.
• Original Assignee: Amgen Inc.
• Inventors: Toledo-Sherman, Leticia M., Bemis, Jean E., Habgood, Gregory J., Elbaum, Daniel, Nunes, Joseph J., Novak, Perry M., Armistead, David M.
• Application Number:
  US10/278,369
• Publication Number:
  US 20040019067A1
• Time in Patent Office: Days
• US Class Current: 514/269
• CPC Class Codes: C07D 239/47 One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
• CPC Class Codes: C07D 239/56 One oxygen atom and one sulfur atom
• CPC Class Codes: C07D 239/70 condensed with carbocyclic rings or ring systems

Abstract

The invention relates to inhibitors of kinases, compositions comprising the inhibitors, and methods of using the inhibitors and inhibitor compositions. The inhibitors and compositions comprising them are useful for treating disease or disease symptoms. The invention also provides for methods of making kinase inhibitor compounds, methods of inhibiting kinase activity, and methods for treating disease or disease symptoms.

Claims

1. A compound of the formula:

2. The compound of claim 1 having the formula:

3. The compound of claim 1 having the formula,

4. The compound of claim 1 having the formula,

5. The compound of claim 1 having the formula,

6. The compound of claim 1 having the formula,

8. A composition comprising a compound according to any of claims 1-7 and a pharmaceutically acceptable carrier.

9. A method of treating a kinase mediated disease or disease symptoms in a mammal comprising administration to said mammal of a compound of any of claims 1-7.

10. A method of inhibiting kinase activity in a mammal comprising the step of administering to said mammal a compound of any of claims 1-7.

11. A method of making a compound of any of claims 1-7 comprising reacting a pyrimidinone of the formula:

12. The method of claim 11, wherein R¹ is CN;

R³ is as defined in any of claims 1-7;

X is O; and

R⁵ is Me.

7. A compound of formula,