Method of treating prostatic diseases using active vitamin D analogues
First Claim
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1. A method of inhibiting the hyperproliferative activity of human prostatic neoplastic or hyperplastic cells, comprising treating the cells with an effective amount of a 1α
- -hydroxyvitamin D compound having a hydrocarbon moiety substituted at C-24.
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Abstract
The invention provides therapeutic methods for inhibiting, ameliorating or alleviating the hyperproliferative cellular activity of diseases of the prostate, e.g., prostatic cancer and prostatic hyperplasia, which includes administering to a patient in need thereof an active vitamin D analogue. Cell differentiation is promoted, induced or enhanced without causing to the patient dose-limiting hypercalcemia and hypercalciuria.
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18 Claims
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1. A method of inhibiting the hyperproliferative activity of human prostatic neoplastic or hyperplastic cells, comprising treating the cells with an effective amount of a 1α
- -hydroxyvitamin D compound having a hydrocarbon moiety substituted at C-24.
- View Dependent Claims (2, 3, 4)
- 5. A method for the treatment of prostatic diseases characterized by abnormal cell differentiation or cell proliferation, comprising administering to a male human or animal in need of such treatment an effective proliferation-inhibiting amount of a compound of formula (I)
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7. A method of treating human prostate cancer, comprising administering to a male subject, who has prostate cancer, an effective amount of a first anticancer agent which is an active vitamin D compound to decrease or stabilize the cellular abnormal proliferative activity of the cancer, said compound or its in vivo metabolite having a VDR binding affinity substantially equivalent to the binding affinity of 1α
- ,25-dihydroxyvitamin D3 and a hypercalcemia risk substantially lower than that of 1α
,25-dihydroxyvitamin D3. - View Dependent Claims (8)
- ,25-dihydroxyvitamin D3 and a hypercalcemia risk substantially lower than that of 1α
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9. A pharmaceutical composition, comprising
(a) a first anticancer agent which is an active vitamin D compound, and (b) an agent selected from the group consisting of (i) a second anticancer agent, (ii) a bone agent, (iii) an androgen control agent and (iv) a 5α - -reductase inhibitor and combinations thereof.
- View Dependent Claims (10, 11, 12, 13, 14, 15, 16, 17)
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18. A method of treating a human to alleviate the hyperproliferative cellular activity of prostatic cancer or hyperplasia, comprising administering to a human in need thereof a therapeutically effective amount of an active vitamin D compound having a hydrocarbon moiety substituted at C-24.
Specification