Active agent delivery device having composite members
First Claim
Patent Images
1. A composite microprojection system, comprising:
- a microprojection member having a top surface and a skin distal surface, said microprojection member including a plurality of stratum corneum-piercing microprojections that project from said skin distal surface;
a substantially rigid matrix member disposed on said microprojection member top surface;
a compressible ring disposed on said microprojection member top surface and surrounding said rigid matrix member; and
a backing membrane disposed on said rigid matrix member and compressible ring.
1 Assignment
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Accused Products
Abstract
A device and method are provided for percutaneous transdermal delivery of a biologically active agent by applying a microprojection array to the skin of a person or animal with a system that has a composite applicator tip and/or a composite microprojection array system.
117 Citations
111 Claims
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1. A composite microprojection system, comprising:
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a microprojection member having a top surface and a skin distal surface, said microprojection member including a plurality of stratum corneum-piercing microprojections that project from said skin distal surface;
a substantially rigid matrix member disposed on said microprojection member top surface;
a compressible ring disposed on said microprojection member top surface and surrounding said rigid matrix member; and
a backing membrane disposed on said rigid matrix member and compressible ring. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. A composite microprojection system, comprising:
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a microprojection member having a top surface and a skin distal surface, said microprojection member including a plurality of stratum corneum-piercing microprojections that project from said skin distal surface, said microprojection member being coated with a biocompatible coating, said biocompatible coating including at least one biologically active agent;
a substantially rigid matrix member disposed on said microprojection member top surface;
a compressible ring disposed on said microprojection member top surface and surrounding said rigid matrix member; and
a backing membrane disposed on said rigid matrix member and compressible ring. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34)
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35. A composite microprojection system, comprising:
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a microprojection member having a top surface and a skin distal surface, said microprojection member including a plurality of stratum corneum-piercing microprojections that project from said skin distal surface, said microprojection member further including a reservoir containing at least one biologically active agent;
a substantially rigid matrix member disposed on said microprojection member top surface;
a compressible ring disposed on said microprojection member top surface and surrounding said rigid matrix member; and
a backing membrane disposed on said rigid matrix member and compressible ring. - View Dependent Claims (36, 37, 38, 39, 40, 41)
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42. A composite microprojection system, comprising:
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a microprojection member having a top surface and a skin distal surface, said microprojection member including a plurality of stratum corneum-piercing microprojections that project from said skin distal surface, said microprojection member further including an agent-containg matrix, said matrix including at least one biologically active agent;
a substantially rigid matrix member disposed on said microprojection member top surface;
a compressible ring disposed on said microprojection member top surface and surrounding said rigid matrix member; and
a backing membrane disposed on said rigid matrix member and compressible ring. - View Dependent Claims (43, 44, 45, 46, 47, 48, 49, 50)
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51. A composite applicator tip for an applicator, the applicator being adapted to apply a microprojection member, the applicator tip comprising:
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a tip member adapted to cooperate with the applicator, said tip member having a skin distal surface; and
a compressible member disposed on said tip member skin distal surface. - View Dependent Claims (52, 53, 54, 55, 56, 57)
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58. A composite applicator tip for an applicator, the applicator being adapted to apply a microprojection member, the applicator tip comprising:
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a tip member adapted to cooperate with the applicator, said tip member having a skin distal surface, said tip member including a substantially continuous recessed region on said skin distal surface; and
a compressible member disposed in said recessed region. - View Dependent Claims (59, 60, 61)
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62. A transdermal delivery system, comprising:
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a microprojection member having a top surface and a skin distal surface, said microprojection member including a plurality of stratum corneum-piercing microprojections that project from said skin distal surface, a substantially rigid matrix member disposed on said microprojection member top surface, a compressible ring disposed on said microprojection member top surface and surrounding said rigid matrix member, and a backing membrane disposed on said rigid matrix member and compressible ring; and
an applicator adapted to apply said microprojection member, said applicator including an applicator tip that is adapted to contact said microprojection member when said applicator is employed to apply said microprojection member. - View Dependent Claims (63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77)
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78. A transdermal delivery system, comprising:
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a microprojection member having a top surface and a skin distal surface, said microprojection member including a plurality of stratum corneum-piercing microprojections that project from said skin distal surface of said microprojection member; and
an applicator adapted to apply said microprojection member, said applicator including an applicator tip having a skin distal surface that is adapted to contact said microprojection member when said applicator is employed to apply said microprojection member, said applicator tip including a compressible member disposed on said skin distal surface of said applicator tip. - View Dependent Claims (79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93)
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94. A transdermal delivery system, comprising:
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a microprojection member having a top surface and a skin distal surface, said microprojection member including a plurality of stratum corneum-piercing microprojections that project from said skin distal surface of said microprojection member, a substantially rigid matrix member disposed on said microprojection member top surface, a first compressible member disposed on said microprojection member top surface and surrounding said rigid matrix member, and a backing membrane disposed on said rigid matrix member and first compressible member; and
an applicator adapted to apply said microprojection member, said applicator including an applicator tip having a skin distal surface that is adapted to contact said microprojection member when said applicator is employed to apply said microprojection member, said applicator tip including a second compressible member disposed on said skin distal surface of said applicator tip. - View Dependent Claims (95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111)
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Specification