Extracorporeal capturing of specific bio-macromolecular entities from extracellular body fluids
First Claim
1. A method for extracorporeal capturing of specific bio-macromolecular entities from extracellular body fluids, said method comprising the steps of:
- (a) obtaining the extracellular body fluid from a mammal;
(b) contacting the obtained extracellular body fluid with a stabilised fluidised bed of adsorption particles characterized by having a specific affinity for the specific bio-macromolecular entities; and
(c) reinfusion of the treated extracellular body fluid into the same mammal;
wherein steps (a) and (c) are performed in a continuous process.
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Abstract
The invention describes a method and devices for extracorporeal capturing of specific bio-macromolecular entities from extracellular body fluids. The method is a column-type process and comprise the extracorporeal circulation of the extracellular body fluids through a stabilised fluidised bed of an adsorbent medium characterized by having specific affinity towards one or more specific bio-macromolecular entities. Also described is a method comprising such extracorporeal circulation through an adsorbent medium in a continuous batch process, said adsorption medium characterised by having specific affinity towards one or more specific bio-macromolecular entities and further being characterised by comprising adsorbent particles having small diameters and high densities.
43 Citations
35 Claims
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1. A method for extracorporeal capturing of specific bio-macromolecular entities from extracellular body fluids, said method comprising the steps of:
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(a) obtaining the extracellular body fluid from a mammal;
(b) contacting the obtained extracellular body fluid with a stabilised fluidised bed of adsorption particles characterized by having a specific affinity for the specific bio-macromolecular entities; and
(c) reinfusion of the treated extracellular body fluid into the same mammal;
wherein steps (a) and (c) are performed in a continuous process. - View Dependent Claims (2, 3, 4, 5, 6, 7, 11, 12, 13, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34)
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8. A method for extracorporeal capturing of specific bio-macromolecular entities from extracellular body fluids, said method comprising the steps of:
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(a) obtaining the extracellular body fluid from a mammal;
(b) contacting the obtained extracellular body fluid with adsorption particles characterized by having a specific affinity for the specific bio-macromolecular entities, and having a density of at least 1.3 g/ml and a mean diameter of in the range of 5-1000 μ
m, such as a density of at least 1.5 g/ml and a mean diameter of in the range of 5-300 μ
m, preferably a density of at least 1.8 g/ml and a mean diameter of in the range of 5-150 μ
m, and most preferred a density of more than 2.5 g/ml and a mean diameter of in the range of 5-75 μ
m,c) reinfusion of the treated extracellular body fluid into the same mammal;
wherein (a) and (c) are performed in a continuous process which does not comprise a continuous centrifugation process. - View Dependent Claims (9, 10, 14)
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35. A method of treating a mammal in need therefore by extracorporeal capturing of specific bio-macromolecular entitles from extracellular body fluids, said method comprising the steps of:
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(a) obtaining the extracellular body fluid from a mammal;
(b) contacting the obtained extracellular body fluid with a stabilised fluidised bed of adsorption particles characterized by having a specific affinity for the specific bio-macromolecular entities; and
(c) reinfusion of the treated extracellular body fluid into the same mammal;
wherein steps (a) and (c) are performed in a continuous process.
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Specification