Method and system for developing and querying a sequence driven contextual knowledge base
First Claim
1. A method of querying and receiving information, wherein the method comprises (a) providing to a query engine a query term;
- (b) matching a nucleic acid sequence tag to the query term;
(c) identifying at least one active knowledge template comprising the information described in context and related by the nucleic acid sequence tag; and
(d) returning the information from the active knowledge template.
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Accused Products
Abstract
Disclosed is a method and system of predictive toxicology in the form of a multigenome knowledge base incorporating gene and protein molecular expression analysis, gene/protein functional annotation, domain specific ontologies, and literature mapping. The knowledge base can be globally queried by means of local sequence alignment as well as by any other knowledge base object. This sequence linkage enables continuous refinement of data quality, information documentation, and integration of new knowledge across species. Any molecular expression profile derived experimentally or in the clinic, representing expressed genes, proteins, or partial sequences known to the knowledge base, can be used to globally query the knowledge base to find common concordant expression profiles reflecting specific clinical observations and measurements that have been indexed and context documented in terms of dose, treatment time and phenotypic severity.
50 Citations
20 Claims
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1. A method of querying and receiving information, wherein the method comprises
(a) providing to a query engine a query term; -
(b) matching a nucleic acid sequence tag to the query term;
(c) identifying at least one active knowledge template comprising the information described in context and related by the nucleic acid sequence tag; and
(d) returning the information from the active knowledge template. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A method of defining active knowledge templates, wherein the method comprises:
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(a) accepting a first set of data;
(b) storing the first set of data;
(c) establishing relationships between the data and one or more nucleic acid sequence tags;
(d) accepting a second set of data; and
(e) modifying relationships between the first data set, the second data set and/or contextual information based on the accepted second data set. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification