Single detector infrared ATR glucose measurement system

• US 20050137469A1
• Filed: 12/17/2003
• Published: 06/23/2005
• Est. Priority Date: 12/17/2003
• Status: Abandoned Application

• Current Assignee: Medoptix Incorporated
• Original Assignee: Medoptix Incorporated
• Inventors: Peyser, Thomas A., Berman, Herbert L.
• Application Number:
  US10/739,657
• Publication Number:
  US 20050137469A1
• Time in Patent Office: Days
• US Class Current: 600/316
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters

Abstract

A single detector infrared ATR glucose measurement system is disclosed herein. The device uses attenuated total reflection infrared spectroscopy. Preferably, the device is used on a fingertip and compares two specific regions of a measured infrared spectrum to determine the blood glucose level of the user. A single IR detector is utilized along with an alternating filter. This device is especially suitable for monitoring glucose levels in the human body, and is especially beneficial to users having diabetes mellitus. The device and procedure may be used for other analyte materials which exhibit unique mid-IR signatures of the type described herein and that are found in appropriate regions of the outer skin.

Claims

1. An analyte level measurement device for measuring analyte levels by contacting a skin surface, comprising:

an infrared source for emitting an IR beam into an ATR plate, the IR beam having components at least in a region of a referencing wavelength and a measuring wavelength,

the ATR plate having a measurement surface for contact with the skin surface and for directing the IR beam against the skin surface,

at least one IR detector for measuring absorbance of at least the referencing wavelength and the measuring wavelength, and

a calculator for determining the analyte level using the measured absorbance of the skin surface.

2. The analyte measurement device of claim 1 wherein the ATR plate is configured to permit multiple internal reflections against the measurement surface.

3. The analyte measurement device of claim 2 wherein the ATR plate is configured for 3-15 internal reflections against the measurement surface.

4. The analyte measurement device of claim 1 further comprising a pressure maintenance member for maintaining adequate pressure of the skin surface against the ATR plate.

5. The analyte measurement device of claim 1 wherein the analyte is glucose and the referencing wavelength is between about 8.25 micrometers and about 8.75 micrometers.

6. The analyte measurement device of claim 1 wherein the analyte is glucose and said measuring wavelength is between about 9.50 micrometers and about 10.00 micrometers.

7. The analyte measurement device of claim 1 further comprising at least two filters situated between the ATR plate and the at least one IR detector.

8. The analyte measurement device of claim 7 wherein the at least two filters are adjacently positioned in a common plane.

9. The analyte measurement device of claim 8 further comprising a transducer adapted to oscillate the at least two filters between a first filter and a second filter.

10. The analyte measurement device of claim 8 further comprising an opaque region disposed between the first filter and the second filter.

11. The analyte measurement device of claim 7 wherein the at least two filters are positioned on a rotatable wheel.

12. The analyte measurement device of claim 11 further comprising a plurality of additional filters.

13. The analyte measurement device of claim 1 further comprising at least one lock-in amplifier in electrical communication with the IR detector.

14. The analyte measurement device of claim 1 further comprising a memory storage unit for storing the measured absorbance.

15. The analyte measurement device of claim 1 further comprising a comparator for comparing the measuring wavelength to the referencing wavelength and providing a signal indicative of blood glucose concentration.

16. The analyte measurement device of claim 15 further comprising a display for displaying the blood glucose concentration.

17. The analyte measurement device of claim 1 wherein the at least one IR detector is adapted to detect the referencing wavelength and the measuring wavelength sequentially.

18. The analyte measurement device of claim 1 wherein the at least one IR detector is adapted to detect the referencing wavelength and the measuring wavelength in an alternating manner.

19. A method for determining an analyte level from a skin surface of a body, comprising:

contacting the skin surface with a surface of an ATR plate;

irradiating the skin surface with an IR beam having components at least in the region of a referencing wavelength and a measuring wavelength through the ATR plate to produce a reflected IR beam indicative of the analyte level in the body;

pulsing the reflected IR beam so as to alternate the referencing wavelength and the measuring wavelength; and

detecting and quantifying the referencing wavelength and the measuring wavelength components in the reflected IR beam as emitted from the skin surface.

20. The method of claim 19 further comprising maintaining the skin surface on the ATR plate at an adequate pressure.

21. The method of claim 19 wherein pulsing the reflected IR beam comprises passing the reflected IR beam through at least two alternating filters.

22. The method of claim 21 wherein pulsing the reflected IR beam further comprises oscillating the at least two filters through the reflected IR beam.

23. The method of claim 21 wherein pulsing the reflected IR beam further comprises rotating the at least two filters about a pivot through the reflected IR beam.

24. The method of claim 19 further comprising sequentially detecting the referencing wavelength and the measuring wavelength components in said reflected IR beam.

25. The method of claim 19 wherein the referencing wavelength is between about 8.25 micrometers and about 8.75 micrometers.

26. The method of claim 19 wherein the measuring wavelength is between about 9.50 micrometers and about 10.00 micrometers.

27. The method of claim 19 further comprising:

measuring an absorbance of the measuring wavelength and providing a measuring signal related to the absorbance of the measuring wavelength; and

measuring the absorbance of the referencing wavelength and providing a referencing signal related to the absorbance of the referencing wavelength.

28. The method of claim 27 further comprising comparing the measuring signal to the referencing signal and providing a signal indicative of blood glucose concentration.

29. The method of claim 28 further comprising calculating the blood glucose concentration using stored calibration constants.

30. The method of claim 29 further comprising displaying the glucose concentration.

31. The method of claim 27 further comprising comparing the measuring signal to the referencing signal with a processor and providing a digital signal indicative of blood glucose concentration.

32. The method of claim 31 further comprising calculating the blood glucose concentration using stored calibration constants.

33. The method of claim 32 further comprising displaying the glucose concentration.