Nasal peptide pharmaceutical formulation
First Claim
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1. A pharmaceutical formulation comprising:
- (1) THAM [tris(hydroxymethyl) aminomethane] as a selective absorbefacient to enhance through the nasal mucosa-lined-epithelium the absorption of substances of peptide nature; and
(2) a therapeutically effective amount of active nasal peptide, its pharmaceutically acceptable salt or its peptidic fragment;
in a pharmaceutically acceptable, aqueous liquid diluent or carrier, said formulation being in a form suitable for nasal administration.
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Abstract
The invention provides a pharmaceutical formulation comprising:
(1) THAM, which is tris(hydroxymethyl)aminomethane, as a selective absorbefacient to enhance through the nasal mucosa-lined epithelium the absorption of substances of peptide nature; and
(2) a therapeutically effective amount of active nasal peptide, its pharmaceutically acceptable salt or its peptidic fragment; in a pharmaceutically acceptable, aqueous liquid diluent or carrier, said formulation being in a form suitable for nasal administration.
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25 Claims
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1. A pharmaceutical formulation comprising:
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(1) THAM [tris(hydroxymethyl) aminomethane] as a selective absorbefacient to enhance through the nasal mucosa-lined-epithelium the absorption of substances of peptide nature; and
(2) a therapeutically effective amount of active nasal peptide, its pharmaceutically acceptable salt or its peptidic fragment;
in a pharmaceutically acceptable, aqueous liquid diluent or carrier, said formulation being in a form suitable for nasal administration. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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Specification