Laser device and method for collapsing hybridization substrate
First Claim
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1. A method for preparing a substrate for hybridization, the method comprising:
- positioning a porous layer on the substrate; and
collapsing a moat in the porous layer with a laser, wherein the moat is adapted to bound a portion of the porous layer on which an array can be positioned.
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Abstract
The present application relates to an apparatus and method for laser collapsing of a porous material on a nonporous substrate.
11 Citations
22 Claims
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1. A method for preparing a substrate for hybridization, the method comprising:
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positioning a porous layer on the substrate; and
collapsing a moat in the porous layer with a laser, wherein the moat is adapted to bound a portion of the porous layer on which an array can be positioned. - View Dependent Claims (2, 3)
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4. A method for manufacturing, comprising:
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providing a substrate comprising a porous layer, wherein the porous layer is adapted for depositing an array;
providing a laser assembly, wherein the laser assembly comprises laser; and
collapsing the moat in the porous layer with the laser. - View Dependent Claims (5)
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6. A method for preparing a hybridization chamber, comprising:
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providing a substrate comprising a porous layer with a moat collapsed with a laser;
positioning an array on a portion of the porous layer bound by the moat; and
positioning a gasket in the moat to provide a nonporous seal.
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7. An apparatus for preparing a hybridization substrate, comprising:
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a laser assembly adapted to collapse a moat in a porous layer on the substrate; and
a galvanometer scan assembly adapted to position laser light from the laser assembly on the porous layer. - View Dependent Claims (8, 9, 10, 11)
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12. A laser assembly, comprising:
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a laser adapted to collapse a moat in a porous layer of a hybridization substrate;
a mechanism to position the laser light on a portion of the porous layer. - View Dependent Claims (13)
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14. A substrate for hybridization, comprising:
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a porous layer, wherein the porous layer is adapted for depositing an array; and
a moat in the porous layer, wherein the moat is collapsed by laser. - View Dependent Claims (15, 16)
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- 17. An apparatus for preparing a substrate for hybridization comprising means for providing a moat in a porous layer on a substrate by laser means, wherein the porous layer is adapted for depositing an array.
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20. A system for automated preparation of substrates for hybridization comprising:
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a first linear actuator to position a laser assembly, wherein the laser assembly comprises a laser and a galvanometer scan assembly, wherein the galvanometer scan assembly is mounted on a second linear actuator, and a third linear actuator to position a slide holder. - View Dependent Claims (21, 22)
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Specification