Surface directed cellular attachment
First Claim
Patent Images
1. A biocompatible substrate having thereon a plurality of first substantially uniform superficial pores and a unique plurality of second substantially uniform superficial pores.
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Accused Products
Abstract
Implantable biomaterials, particularly hydrogel substrates with porous surfaces, and methods for enhancing the compatibility of biomaterials with living tissue, and for causing physical attachment between biomaterials and living tissues are provided. Also provided are implants suitable for load-bearing surfaces in hard tissue repair, replacement, or augmentation, and to methods of their use. One embodiment of the invention relates to an implantable spinal disc prosthesis.
156 Citations
44 Claims
- 1. A biocompatible substrate having thereon a plurality of first substantially uniform superficial pores and a unique plurality of second substantially uniform superficial pores.
- 11. A hydrogel substrate comprising a hydrogel surface having thereon a plurality of first substantially uniform superficial pores and a unique plurality of second substantially uniform superficial pores.
- 24. A hydrogel substrate which promotes attachment of cartilage comprising a hydrogel surface having thereon a plurality of first substantially uniform superficial pores and a unique plurality of second substantially uniform superficial pores.
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37. A method of making a biomaterial substrate comprising a surface having thereon a plurality of first substantially uniform superficial pores and a unique plurality of second substantially uniform superficial pores comprising:
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a. providing a mold having projections thereon corresponding to first and second pores, b. casting the biomaterial in the mold, c. allowing the substrate to form while in the mold, and d. removing the substrate from the mold. - View Dependent Claims (38)
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39. A method of making a hydrogel substrate comprising a hydrogel surface having thereon a plurality of first substantially uniform superficial pores and a unique plurality of second substantially uniform superficial pores comprising:
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a. providing a mold having projections thereon corresponding to first and second pores, b. pouring a liquid solution of the hydrogel into the mold, c. allowing the hydrogel to polymerize and crosslink while in the mold, and d. removing the solid hydrogel from the mold. - View Dependent Claims (40, 42, 43)
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44. A hydrogel substrate comprising at least two regions of differing superficial pore sizes.
Specification