Identification of the gene and mutation for progressive rod-cone degeneration in dog and a method for testing same
First Claim
Patent Images
1. A method for identifying a dog as genetically normal, as a carrier of, or as predisposed to progressive rod cone degeneration comprising:
- a) obtaining a biological sample comprising nucleic acids from the dog; and
b) testing the biological sample comprising nucleic acids for a G to A transversion in the F04 gene at a position corresponding to nucleotide position 1298 of SEQ ID NO;
1, wherein the G to A transversion in one allele is indicative of a carrier of progressive rod-cone degeneration, the G to A transversion in both alleles is indicative of a dog affected with or predisposed to progressive rod-cone degeneration, and the absence of the G to A transversion is indicative of a genetically normal dog.
3 Assignments
0 Petitions
Accused Products
Abstract
Tools and methods are provided for determining whether or not a dog is genetically normal, is a carrier of, or is affected with or predisposed to progressive rod-cone degeneration. The method is based on the detection of a transversion from G to A at position corresponding to nucleotide position 1298 of SEQ ID NO: 1.
1 Citation
16 Claims
-
1. A method for identifying a dog as genetically normal, as a carrier of, or as predisposed to progressive rod cone degeneration comprising:
-
a) obtaining a biological sample comprising nucleic acids from the dog; and
b) testing the biological sample comprising nucleic acids for a G to A transversion in the F04 gene at a position corresponding to nucleotide position 1298 of SEQ ID NO;
1, wherein the G to A transversion in one allele is indicative of a carrier of progressive rod-cone degeneration, the G to A transversion in both alleles is indicative of a dog affected with or predisposed to progressive rod-cone degeneration, and the absence of the G to A transversion is indicative of a genetically normal dog. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
-
-
15. An isolated polynucleotide comprising a DNA sequence of SEQ ID NO:
- 1, a RNA sequence corresponding to SEQ ID NO;
1, a DNA sequence complementary to SEQ ID NO;
1 or a RNA sequence complementary to SEQ ID NO;
1.
- 1, a RNA sequence corresponding to SEQ ID NO;
-
16. An isolated polynucleotide comprising a DNA sequence of SEQ ID NO:
- 3, a RNA sequence corresponding to SEQ ID NO;
3, a DNA sequence complementary to SEQ ID NO;
3 or a RNA sequence complementary to SEQ ID NO;
3.
- 3, a RNA sequence corresponding to SEQ ID NO;
Specification