Analyzer, analyzing method, and blood-sugar level measuring device

• US 20060029991A1
• Filed: 08/02/2005
• Published: 02/09/2006
• Est. Priority Date: 08/04/2004
• Status: Abandoned Application

• Current Assignee: Sysmex Corporation
• Original Assignee: Sysmex Corporation
• Inventors: Sato, Toshiyuki, Maekawa, Yasunori, Okada, Seiki, Sawa, Kennichi, Hagino, Kei, Asakura, Yoshihiro
• Application Number:
  US11/194,462
• Publication Number:
  US 20060029991A1
• Time in Patent Office: Days
• US Class Current: 435/14
• CPC Class Codes: A61B 5/0531 Measuring skin impedance
• CPC Class Codes: A61B 5/14514 using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/681 Wristwatch-type devices
• CPC Class Codes: A61N 1/30 Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis

Abstract

An analyzer including an electrical information acquiring section for acquiring an electrical information by supplying an electricity to a skin of a subject; and a controller for acquiring a component value relating to an amount of a predetermined component included in a tissue fluid extracted via the skin of the subject and converting the component value into a concentration of the predetermined component included in the tissue fluid in a body of the subject based on the electrical information acquired by the electrical information acquiring section is disclosed. An analyzing method and a blood-sugar level measuring device are also disclosed.

Claims

1. An analyzer comprising:

an electrical information acquiring section for acquiring an electrical information by supplying an electricity to a skin of a subject; and

a controller for acquiring a component value relating to an amount of a predetermined component included in an extraction tissue fluid extracted via the skin of the subject and converting the component value into a concentration of the predetermined component included in an internal tissue fluid existed in a body of the subject based on the electrical information acquired by the electrical information acquiring section.

2. An analyzer according to claim 1, wherein

the controller calculates an electric resistance value of a portion of an epidermis through which the extraction tissue fluid passes based on the electrical information and converts the component value into the concentration of the predetermined component included in the internal tissue fluid existed in the body of the subject based on the electric resistance value.

3. An analyzer according to claim 1, wherein

the electrical information acquiring section comprises a first electrode, a second electrode, a third electrode, and a power supply connected to the first electrode, the second electrode and the third electrode, and

the electrical information includes a first electrical information acquired by supplying first current running through the first electrode, the skin and the second electrode by the power supply, a second electrical information acquired by supplying second current running through the first electrode, the skin and the third electrode by the power supply, and a third electrical information acquired by supplying third current running through the second electrode, the skin and the third electrode by the power supply.

4. An analyzer according to claim 3, wherein

the power supply supplies fourth current running through the first electrode, the skin and the second electrode to extract the extraction tissue fluid, and

the controller acquires the component value relating to the amount of the predetermined component included in the extraction tissue fluid extracted by supplying the fourth current by the power supply.

5. An analyzer according to claim 3, further comprising:

a retaining unit for retaining the second electrode and the third electrode electrically separated from the second electrode and being held by a hand of the subject in a state where the second electrode and the third electrode are in contact with the skin.

6. An analyzer according to claim 1, wherein

the electrical information includes a magnitude of the current running through the skin of the subject.

7. An analyzer according to claim 1, wherein

the electrical information includes a magnitude of a voltage applied to the skin of the subject.

8. An analyzer according to claim 1, further comprising a detector for detecting the predetermined component included in the extraction tissue fluid extracted via the skin of the subject, wherein

the controller acquires the component value based on a detection result of the detector.

9. An analyzer according to claim 8, wherein

the controller acquires a speed at which the predetermined component included in the extraction tissue fluid is extracted via the skin as the component value based on the detection result of the detector and a time period required for extracting the predetermined component.

10. An analyzer according to claim 1, further comprising a tissue fluid retaining material for retaining the extraction tissue fluid.

11. An analyzer according to claim 2, further comprising a tissue fluid retaining material for retaining the extraction tissue fluid, wherein

the portion of the epidermis through which the extraction tissue fluid passes is a portion in contact with the tissue fluid retaining material.

12. An analyzer according to claim 1, wherein

the component value is a value relating to a glucose amount, and the concentration of the predetermined component included in the internal tissue fluid existed in the body of the subject is a glucose concentration.

13. An analyzer according to claim 12, wherein

the glucose concentration is a blood-sugar level of the subject.

14. An analyzer according to claim 1, further comprising:

a main body comprising the electrical information acquiring section and the controller; and

a fixing member for fixing the main body to the skin of the subject in a state in which the main body is placed on the skin.

15. An analyzing method comprising:

an extracting step for extracting an extraction tissue fluid from a body of a subject via a skin;

a component amount acquiring step for acquiring a component value relating to an amount of a predetermined component included in the extraction tissue fluid extracted in the extracting step;

an electrical information-acquiring step for acquiring an electrical information by supplying an electricity to the skin; and

a component concentration acquiring step for converting the component value into a concentration of the predetermined component included in an internal tissue fluid existed in the body of the subject based on the electrical information acquired in the electrical information acquiring step.

16. An analyzing method according to claim 15, further comprising extraction holes forming step for forming extraction holes penetrating through a stratum corneum but not reaching a subcutaneous tissue in the skin prior to the implementation of the extracting step, wherein the extraction tissue fluid is extracted via the extraction holes in the extracting step.

17. An analyzing method according to claim 16, wherein

the extraction tissue fluid is extracted by supplying a liquid in the extraction holes in the extracting step.

18. A blood-sugar level measuring device comprising:

an electrical information acquiring section for acquiring an electrical information by supplying an electricity to a skin of a subject; and

a controller for acquiring a glucose value relating to a glucose amount included in an extraction tissue fluid extracted via the skin of the subject and converting the glucose value into a blood-sugar level of the subject based on the electrical information acquired by the electrical information acquiring section.

19. A blood-sugar level measuring device according to claim 18, wherein

the controller converts the glucose value into a concentration of the glucose included in an internal tissue fluid exisited in a body of the subject based on the electrical information acquired by the electrical information acquiring section, and

the concentration of the glucose included in the internal tissue fluid exisited in the body of the subject is the blood-sugar level of the subject.

20. A blood-sugar level measuring device according to claim 18, wherein

the controller converts the glucose value into a concentration of the glucose included in an internal tissue fluid existed in a body of the subject based on the electrical information acquired by the electrical information acquiring section, and further converts the concentration of the glucose into the blood-sugar level of the subject.