Clotting cascade initiating apparatus and methods of use and methods of closing wounds
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Accused Products
Abstract
Wound closure methods and apparata are provided which utilize blood fluid by activating the clotting cascade of the blood fluid outside the body within a substantially enclosed sterile container then introducing the blood fluid to the wound site to complete clotting. Methods and apparata for providing ways of inhibiting anticoagulants and slowing fibrin clot degradation are also disclosed. Kits for practicing the invention singularly or in combination with and/or associated with preferred procedures are also disclosed.
55 Citations
66 Claims
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1-47. -47. (canceled)
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48. A method of treating blood for use in closing a wound in a patient, the method comprising the steps of:
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a) treating a blood volume with an agent which assists in or enhances the clotting or coagulation of the blood volume such that at least a portion of the blood volume will form a clot of blood subsequent to the treatment, the blood volume containing sufficient blood components to enable a portion of the blood volume to clot subsequent to the treatment once a clotting cascade is initiated, the blood components being selected from the group consisting of whole blood, natural components of whole blood, whether derived from whole blood, blood extracts, and products of ex vivo cell cultures, and the step of treating the blood volume including initiating the clotting cascade; and
b) removing the agent from the treated blood volume. - View Dependent Claims (49, 50, 51, 52, 53, 54, 55, 56, 57)
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58. A method of treating a volume of blood for use in closing a wound in a patient, the method comprising the steps of:
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a) treating a blood volume with an agent which assists in or enhances the clotting or coagulation of the blood volume such that at least a portion of the blood volume will form a clot of blood subsequent to the treatment, the blood volume containing sufficient blood components to enable a portion of the blood volume to clot subsequent to the treatment once a clotting cascade is initiated, the blood components being selected from the group consisting of whole blood, natural components of whole blood, whether derived from whole blood, blood extracts, and products of ex vivo cell cultures, and the step of treating the blood volume including initiating the clotting cascade; and
b) removing the agent from the treated blood volume. - View Dependent Claims (59, 60, 61, 62, 63, 64, 65, 66)
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Specification