Directed differentiation of embryonic stem cells and uses thereof
First Claim
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1. A method for directed differentiation of embryonic stem (ES) cells into pancreatic lineage, comprising:
- contacting the ES cells for a sufficient period of time with a sufficient amount of one or more early factors (EFs) selected from activin A, BMP2, BMP4, or nodal, wherein the pancreatic lineage cells express pancreatic lineage marker(s), and/or exhibit a pancreatic lineage function.
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Abstract
The present invention provides methods for the directed differentiation of embryonic stem cells along the endodermal lineage, especially the pancreatic lineage.
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42 Claims
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1. A method for directed differentiation of embryonic stem (ES) cells into pancreatic lineage, comprising:
- contacting the ES cells for a sufficient period of time with a sufficient amount of one or more early factors (EFs) selected from activin A, BMP2, BMP4, or nodal, wherein the pancreatic lineage cells express pancreatic lineage marker(s), and/or exhibit a pancreatic lineage function.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42)
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