Non-Invasive Analyte Measurement Device for Measuring Tears and Other Ocular Elements Using Electromagnetic Radiation and Method of Using the Same
First Claim
8. A method of non-invasively measuring the presence, absence or concentration of one or more analytes in an ocular element of a subject, the subject including an eye with an ocular surface and multiple ocular elements, comprising:
- measuring the presence, absence or concentration of the one or more analytes from the eye by profiling more than one different ocular element to determine an ideal ocular element for measuring the presence, absence or concentration of the one or more analytes;
measuring the presence, absence or concentration of one or more analytes from the ideal ocular element by exposing at least a portion of the ideal ocular element to electromagnetic radiation without contact with the ocular element;
detecting electromagnetic radiation reflected from the ocular element without contact with the ocular element; and
determining a radiation signature of the reflected electromagnetic radiation to determine the presence, absence or concentration of the one or more analytes in the ocular element of the subject.
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Accused Products
Abstract
A method of non-invasively measuring the presence, absence or concentration of one or more analytes in an ocular element of a subject, the subject including an eye with an ocular surface and a tear layer, includes exposing at least a portion of the tear layer and/or other ocular elements of the subject to electromagnetic radiation without contact with the ocular surface; detecting electromagnetic radiation reflected from the tear layer and/or other ocular elements without contact with the ocular surface; and determining a radiation signature of the reflected electromagnetic radiation to determine the presence, absence or concentration of the one or more analytes in the tear layer and/or other ocular elements of the subject.
100 Citations
26 Claims
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8. A method of non-invasively measuring the presence, absence or concentration of one or more analytes in an ocular element of a subject, the subject including an eye with an ocular surface and multiple ocular elements, comprising:
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measuring the presence, absence or concentration of the one or more analytes from the eye by profiling more than one different ocular element to determine an ideal ocular element for measuring the presence, absence or concentration of the one or more analytes;
measuring the presence, absence or concentration of one or more analytes from the ideal ocular element by exposing at least a portion of the ideal ocular element to electromagnetic radiation without contact with the ocular element;
detecting electromagnetic radiation reflected from the ocular element without contact with the ocular element; and
determining a radiation signature of the reflected electromagnetic radiation to determine the presence, absence or concentration of the one or more analytes in the ocular element of the subject. - View Dependent Claims (9, 10, 11, 12, 13)
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14. A non-invasive analyte measurement instrument for determining the presence, absence or concentration of one or more analytes in an ocular element of a subject, the subject including an eye with an ocular surface and a tear layer, comprising:
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means for exposing at least a portion of the tear layer of the subject to electromagnetic radiation without contact with the ocular surface;
means for detecting electromagnetic radiation reflected from the tear layer without contact with the ocular surface; and
means for determining a radiation signature of the reflected electromagnetic radiation to determine the presence, absence or concentration of the one or more analytes in the ocular element of the subject. - View Dependent Claims (15, 16, 17, 18)
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19. A non-invasive analyte measurement instrument for determining the presence, absence or concentration of one or more analytes in an ocular element of a subject, the subject including an eye with an ocular surface and multiple ocular elements, comprising:
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means for profiling more than one different ocular element to determine an ideal ocular element for measuring analyte concentration;
means for measuring the presence, absence or concentration of one or more analytes from the ideal ocular element, including means for exposing at least a portion of the ideal ocular element to electromagnetic radiation without contact with the ocular element;
means for detecting electromagnetic radiation reflected from the ocular element without contact with the ocular element; and
means for determining a radiation signature of the reflected electromagnetic radiation to determine the presence, absence or concentration of the one or more analytes in the ocular element of the subject. - View Dependent Claims (1, 2, 3, 4, 5, 6, 7, 20, 21)
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20-1. The instrument of claim 19, wherein the detecting means includes specular reflection optics.
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22. A method of non-invasively measuring the presence, absence or concentration of one or more analytes in one or more ocular elements of a subject, the subject including an eye with an ocular surface, comprising:
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exposing at least a portion of the one or more ocular elements of the subject to electromagnetic radiation without contact with the ocular surface;
detecting electromagnetic radiation reflected from the one or more ocular elements without contact with the ocular surface; and
determining a radiation signature of the reflected electromagnetic radiation to determine the presence, absence or concentration of the one or more analytes in the one or more ocular elements of the subject. - View Dependent Claims (23, 24)
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25. A non-invasive analyte measurement instrument for determining the presence, absence or concentration of one or more analytes in one or more ocular elements of a subject, the subject including an eye with an ocular surface, comprising:
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means for exposing at least a portion of the one or more ocular elements of the subject to electromagnetic radiation without contact with the ocular surface;
means for detecting electromagnetic radiation reflected from the one or more ocular elements without contact with the ocular surface; and
means for determining a radiation signature of the reflected electromagnetic radiation to determine the presence, absence or concentration of the one or more analytes in the one or more ocular elements of the subject. - View Dependent Claims (26)
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Specification