SEM cathodoluminescent imaging using up-converting nanophosphors
First Claim
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1. A method for high resolution tissue imaging comprising labeling a tissue to be imaged with UCP'"'"'s coupled to probes that bind specifically to biological markers on said tissue;
- exciting said UCP'"'"'s with electrons so that said UCP'"'"'s emit cathodoluminescent photons; and
converting the photon emission to a visible image.
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Abstract
Methods for high resolution tissue imaging in which a tissue to be imaged is labeled with UCP'"'"'s coupled to probes that bind specifically to biological markers on the tissue; the UCP'"'"'s are then excited with electrons so that the UCP'"'"'s emit cathodoluminescent photons; after which the photon emission is converted to a visible image. Methods for measuring water content, blood content or blood oxygenation in tumor tissue are also disclosed.
29 Citations
21 Claims
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1. A method for high resolution tissue imaging comprising labeling a tissue to be imaged with UCP'"'"'s coupled to probes that bind specifically to biological markers on said tissue;
- exciting said UCP'"'"'s with electrons so that said UCP'"'"'s emit cathodoluminescent photons; and
converting the photon emission to a visible image. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
- exciting said UCP'"'"'s with electrons so that said UCP'"'"'s emit cathodoluminescent photons; and
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13. A method for measuring two or more of water content, blood content or blood oxygenation in tumor tissue comprising, labeling tumor tissue with UCP'"'"'s coupled to probes that bind specifically to biological markers on said tumor;
- exciting said UCP'"'"'s with infrared photons or electrons so that said UCP'"'"'s emit luminescent or cathodoluminescent photons; and
converting the photon emission to information on two or more of water content, blood content or blood oxygenation via spectral analysis. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21)
- exciting said UCP'"'"'s with infrared photons or electrons so that said UCP'"'"'s emit luminescent or cathodoluminescent photons; and
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