Artificial heart valve

• US 20060271171A1
• Filed: 04/03/2006
• Published: 11/30/2006
• Est. Priority Date: 04/01/2005
• Status: Abandoned Application

• Current Assignee: Clemson University, MUSC Foundation For Research Development (State of South Carolina)
• Original Assignee: Clemson University
• Inventors: Beasley, Donald, McQuinn, Tim C., Figliola, Richard
• Application Number:
  US11/396,947
• Publication Number:
  US 20060271171A1
• Time in Patent Office: Days
• US Class Current: 623/2.100
• CPC Class Codes: A61F 2/2445 Annuloplasty rings in direct contact with the valve annulus
• CPC Class Codes: A61F 2002/068 Modifying the blood flow model, e.g. by diffuser or deflector

Abstract

Provided herein is a cardiac valve prosthesis comprising a annulus body having a back face and defining a passage for the flow of blood along an axis of the passage. The passage has a first open end having a greater diameter that its opposed second open end. In a further aspect, the valve prosthesis includes means for creating a fluid barriers to the flow of fluid therethrough the passage of the annulus body.

Claims

1. A cardiac valve prosthesis, comprising:

an annulus body defining a passage therethough having a first open end and a second open end, wherein at least a portion of an inner surface of the passage tapers inwardly toward a longitudinal axis of the annulus body as the passage extends from the first open end to the second open end, wherein the diameter of the first open end is greater than the diameter of the second open end, and wherein the valve prosthesis is configured to replace a deficient native valve.

2. The cardiac valve of claim 1, wherein the annulus body further comprises a back face that surrounds at least a portion of the second open end.

3. The cardiac valve of claim 2, wherein the annulus body further comprises a first conduit that is in fluid communication with the back face and the inner surface of the passage.

4. The cardiac valve of claim 3, wherein the first conduit is configured to direct fluid flowing into the passage at a flow angle of 90 degrees or less with respect to the longitudinal axis of the annulus body and in a direction generally toward the second open end.

5. The cardiac valve of claim 4, wherein the flow angle is between about 90 degress and about 30 degrees.

6. The cardiac valve of claim 3, wherein the annulus body further comprises a second conduit that is in fluid communication with the back face and a circumferential outer surface of the annulus body.

7. The cardiac valve of claim 6, wherein the second conduit is in fluid communication with the first conduit.

8. The cardiac valve of claim 1, wherein the valve prosthesis is sized to replace a human pulmonic valve.

9. The cardiac valve of claim 1, wherein the valve prosthesis is sized to replace a human aortic valve.

10. The cardiac valve of claim 1, wherein the valve prosthesis is sized to replace a human atrioventricular valve.

11. The cardiac valve of claim 1, wherein the valve prosthesis is configured such that the passage remains substantially patent during systole and diastole.

12. The cardiac valve of claim 11, wherein at least a portion of the annulus body is sufficiently resilient to allow in situ expansion and contraction throughout the cardiac cycle.

13. The cardiac valve of claim 1, wherein the passage comprises an inwardly tapering portion and a second portion, the inwardly tapering portion extending a predetermined distance from the first open end and is connected to the second portion, and wherein the second portion extends to the second open end.

14. The cardiac valve of claim 13, wherein the inwardly tapering portion of the passage has a substantially elliptical curvature is cross-section.

15. The cardiac valve of claim 13, wherein the inwardly tapering portion of the passage has a curvature in cross-section that is selected from the group consisting of a circle, a cubic polynomial, and spline based.

16. The cardiac valve of claim 13, wherein the second portion of the passage extends substantially parallel to the longitudinal axis of the annulus body.

17. The cardiac valve of claim 13, wherein the second portion of the passage is outwardly tapering as it extends to the second open end of the annulus body.

18. The cardiac valve of claim 1, wherein the ratio of the diameter of the first open end to the diameter of the second open end is between about 0.4 and about 0.8.

19. The cardiac valve of claim 18, wherein the ratio is between about 0.5 and about 0.7.

20. The cardiac valve of claim 1, wherein the annulus body is resilient.

21. The cardiac valve of claim 20, wherein at least a portion of the passage is configured to narrow during diastole.

22. The cardiac valve of claim 20, wherein the annulus body is configured to the collapsible for transluminal delivery.

23. The cardiac valve of claim 22, wherein the annulus body is configured to be expandable to contact the anatomical annulus of the native valve when the valve prosthesis is positioned in situ.

24. The cardiac valve of claim 1, wherein the annulus body further comprises an anchor for engaging the lumen wall for preventing substantially migration of the valve prosethesis after placement in the desired anatomical position.

25. The cardiac valve of claim 24, wherein the anchor comprises at least one circumferentially extending ring member extending outwardly from an outer surface of the annulus body, whereby the ring member is configured for suturing.

26. The cardiac valve of claim 1, wherein the annulus body comprises natural tissue.

27. The cardiac valve of claims 1 or 26, wherein the annulus body comprises synthetic material.

28. The cardiac valve of claim 1, wherein the annulus body is self-expanding.

29. The cardiac valve of claim 24, wherein the annulus body comprises wire.

30. The cardiac valve of claim 2, wherein the back face of the annulus body defines a circumferentially extending trough that has a substantially hook-shaped cross-sectional shape.

32. The method of claim 26, further comprising the step of excising the native valve.

31. A method of replacing a deficient native valve, comprising the steps of:

providing a cardiac valve prosthesis comprising an annulus body defining a passage therethough having a first open end and a second open end, the passage having an inner surface, wherein at least a portion of the inner surface of the passage tapers inwardly toward a longitudinal axis of the annulus body as the passage extends inwardly from the first open end to the second open end, and wherein the diameter of the first open end is greater than the diameter of the second open end;

collapsing the annulus body to fit within a distally positioned sheath on a catheter;

advancing the catheter to the deficient native valve;

deploying the annulus body of the valve prosthesis; and

withdrawing the catheter, leaving the valve prosthesis to function in place of the deficient native valve.