Liquid crystal polymer syringes and containers and methods of use for long term storage of filler materials

• US 20070003584A1
• Filed: 06/16/2006
• Published: 01/04/2007
• Est. Priority Date: 06/16/2005
• Status: Abandoned Application

• Current Assignee: Artes Medical USA Inc.
• Original Assignee: Artes Medical USA Inc.
• Inventors: Anderson, Russell
• Application Number:
  US11/454,537
• Publication Number:
  US 20070003584A1
• Time in Patent Office: Days
• US Class Current: 424/401
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: A61M 2202/095 Collagen
• CPC Class Codes: A61M 37/0069 Devices for implanting pellets, e.g. markers or solid medicaments for introducing of radioactive sources for interstitial radiation therapy, i.e. brachytherapy A61N5/1027
• CPC Class Codes: A61M 5/3129 Syringe barrels A61M5/3205 and A61M5/50 take precedence

Abstract

A syringe or container including a barrier surface for the long term storage of filler compositions and pre-filled syringes having a barrier surface that include filler compositions are provided.

Claims

1. A pre-filled syringe comprising a barrel and a filler composition, wherein said barrel comprises liquid crystal polymer.

2. The pre-filled syringe of claim 1, wherein said liquid crystal polymer comprises one or more of styrene methylmethacrylate co polymer, Zenite®

, or cyclic olefin copolymer (COP) of ethylene and norbornene.

3. The pre-filled syringe of claim 2, wherein said barrel consists essentially of liquid crystal polymer.

4. The pre-filled syringe of claim 1, wherein said filler composition is a soft tissue filler.

5. The pre-filled syringe of claim 4, wherein said soft tissue filler comprises PMMA microspheres.

6. The pre-filled syringe of claim 5, wherein said soft tissue filler comprises collagen.

7. The pre-filled syringe of claim 5, wherein said soft tissue filler comprises approximately 20% by weight PMMA and approximately 80% by weight a composition comprising 3.5% purified bovine collagen, 2.7% phosphate buffer, 0.9% sodium chloride, 0.3% lidocaine hydrochloride, and 92.6% water for injection.

8. The pre-filled syringe of claim 1, further comprising a plunger, wherein contents-contacting surfaces of said plunger comprise a liquid crystal polymer.

9. The pre-filled syringe of claim 8, wherein said liquid crystal polymer comprises one or more of styrene methylmethacrylate co polymer, ZENITE®

, or cyclic olefin copolymer (COP) of ethylene and norbornene.

10. The pre-filled syringe of claim 8, wherein said plunger consists essentially of liquid crystal polymer.

11. The pre-filled syringe of claim 8, wherein said filler composition is a soft tissue filler.

12. The pre-filled syringe of claim 11, wherein said soft tissue filler comprises PMMA microspheres.

13. The pre-filled syringe of claim 11, wherein said soft tissue filler comprises collagen.

14. The pre-filled syringe of claim 12, wherein said soft tissue filler comprises approximately 20% by weight PMMA and approximately 80% by weight a composition of 3.5% purified bovine collagen, 2.7% phosphate buffer, 0.9% sodium chloride, 0.3% lidocaine hydrochloride, and 92.6% water for injection.

15. The pre-filled syringe of claim 1, further comprising a needle, wherein contents-contacting surfaces of said needle comprises a liquid crystal polymer.

16. The pre-filled syringe of claim 15, wherein said liquid crystal polymer comprises one or more of styrene methylmethacrylate co polymer, ZENITE®

, or cyclic olefin copolymer (COP) of ethylene and norbornene.

17. The pre-filled syringe of claim 15, wherein said needle consists essentially of liquid crystal polymer.

18. The pre-filled syringe of claim 15, wherein said filler composition is a soft tissue filler.

19. The pre-filled syringe of claim 18, wherein said soft tissue filler comprises PMMA microspheres.

20. The pre-filled syringe of claim 18, wherein said soft tissue filler comprises collagen.

21. The pre-filled syringe of claim 19, wherein said soft tissue filler comprises approximately 20% by weight PMMA and 80% by weight a composition of 3.5% purified bovine collagen, 2.7% phosphate buffer, 0.9% sodium chloride, 0.3% lidocaine hydrochloride, and 92.6% water for injection.

22. A pre-filled syringe comprising a barrel, an interior sleeve, and a filler composition, wherein said sleeve comprises liquid crystal polymer.

23. The pre-filled syringe of claim 22, wherein said liquid crystal polymer comprises one or more of styrene methylmethacrylate co polymer, ZENITE®

, or cyclic olefin copolymer (COP) of ethylene and norbornene.

24. The pre-filled syringe of claim 22, wherein said interior sleeve consists essentially of liquid crystal polymer.

25. The pre-filled syringe of claim 22, wherein said filler composition is a soft tissue filler.

26. The pre-filled syringe of claim 25, wherein said soft tissue filler comprises PMMA microspheres.

27. The pre-filled syringe of claim 25, wherein said soft tissue filler comprises collagen.

28. The pre-filled syringe of claim 26, wherein said soft tissue filler comprises approximately 20% by weight PMMA and 80% by weight a composition of 3.5% purified bovine collagen, 2.7% phosphate buffer, 0.9% sodium chloride, 0.3% lidocaine hydrochloride, and 92.6% water for injection.

29. The pre-filled syringe of claim 24, wherein said interior sleeve is deformable.

30. A method for the stable storage of a filler material comprising filling a syringe comprising a liquid crystal polymer with filler material and sealing said syringe.

31. The method of claim 30, wherein said liquid crystal polymer comprises one or more of styrene methylmethacrylate co polymer, ZENITE®

, or cyclic olefin copolymer (COP) of ethylene and norbornene.

32. The method of claim 30, wherein said filler composition is a soft tissue filler.

33. The method of claim 30, wherein said soft tissue filler comprises PMMA microspheres.

34. The method of claim 30, wherein said soft tissue filler comprises collagen.

35. The method of claim 33, wherein said soft tissue filler comprises approximately 20% by weight PMMA and approximately 80% by weight a composition of 3.5% purified bovine collagen, 2.7% phosphate buffer, 0.9% sodium chloride, 0.3% lidocaine hydrochloride, and 92.6% water for injection.