Method of preparing biocompatible silicon nanoparticles

• US 20070098988A1
• Filed: 10/27/2006
• Published: 05/03/2007
• Est. Priority Date: 10/28/2005
• Status: Abandoned Application

• Current Assignee: Korea Advanced Institute of Science and Technology
• Original Assignee: Korea Advanced Institute of Science and Technology
• Inventors: Choi, Won Jun, Lee, Jung Il, Lee, Soojin, Cho, Woon Jo, Han, Il Ki, Park, Jae Gwan
• Application Number:
  US11/588,621
• Publication Number:
  US 20070098988A1
• Time in Patent Office: Days
• US Class Current: 428/403
• CPC Class Codes: A61K 49/0067 quantum dots, fluorescent nanocrystals
• CPC Class Codes: B01J 13/00 Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
• CPC Class Codes: B82Y 30/00 Nanotechnology for materials or surface science, e.g. nanocomposites
• CPC Class Codes: C01B 33/021 Preparation chemical coating from the vapour phase C23C16/00
• CPC Class Codes: Y10T 428/2991 Coated

Abstract

There is provided a method of preparing biocompatible silicon nanoparticles, which comprises the steps of forming a silicon nanoparticle colloid by ultrasonic treatment of Si-containing Zintl salt in diethylene glycol diethyl ether (DGDE), and introducing hydroxyl groups into the surface of the silicon nanoparticle by treating the silicon nanoparticle colloid with a halogenated hydrogen solution. The method of the present invention can easily mass-produce silicon nanoparticles having high dispersion stability in an aqueous solution and biocompatibility in a high yield.

Claims

1. A method of preparing biocompatible silicon nanoparticles, the method comprising the steps of:

i) obtaining a silicon nanoparticle colloid by ultrasonic treatment of a Si-containing zintle salt in diethylene glycol diethyl ether (DGDE); and

ii) adding a halogenated hydrogen solution to the silicon nanoparticle colloid obtained in step (i) and stirring the mixture.

2. The method of claim 1, wherein the Si-containing zintle salt is selected from the group consisting of lithium silicide (LiSi), sodium silicide (NaSi), potassium silicide (KSi), magnesium silicide (Mg_xSi, wherein x is 0.5≦

x≦

2) and calcium silicide (Ca_xSi, wherein x is 0.5≦

x≦

2).

3. The method of claim 1, wherein the ultrasonic treatment is performed by irradiating ultrasonic waves having an electric power ranging from 10 to 2000 W and a frequency ranging from 1 to 100 kHz at room temperature for a minute to 10 hours.

4. The method of claim 1, wherein the ultrasonic treatment is performed by using a ultrasonic probe having a diameter ranging from 1 to 20 mm.

5. The method of claim 1, wherein the halogenated hydrogen is selected from the group consisting of HF, HCI, HBr and HI.

6. The method of claim 1, wherein the concentration of the halogenated hydrogen solution ranges from 1 to 35%.

7. A biocompatible silicon nanoparticle prepared according to the method of any one of claims 1 to 6, a surface of which is modified with hydroxyl groups.