Analyte Sensor, and Associated System and Method Employing a Catalytic Agent

• US 20070191701A1
• Filed: 04/11/2007
• Published: 08/16/2007
• Est. Priority Date: 02/09/2004
• Status: Abandoned Application

• Current Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Inventors: Heller, Adam, Liu, Zenghe, Feldman, Benjamin, Cohen, David
• Application Number:
  US11/734,272
• Publication Number:
  US 20070191701A1
• Time in Patent Office: Days
• US Class Current: 600/347
• CPC Class Codes: A61B 5/14514 using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
• CPC Class Codes: A61B 5/14528 invasively
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/686 Permanently implanted devices, e.g. pacemakers, other stimulators, biochips A61B5/6861 takes precedence
• CPC Class Codes: C12Q 1/002 Electrode membranes
• CPC Class Codes: C12Q 1/004 mediator-assisted
• CPC Class Codes: C12Q 1/005 involving specific analytes or enzymes including groups of enzymes, e.g. oxydases; C12Q1/004 takes precedence
• CPC Class Codes: C12Q 1/006 for glucose

Abstract

An analyte sensor for use in connection with a biofluid is described. The analyte sensor may comprise any suitable interface between the biofluid and a derivative of the biofluid and any suitable transducer of information concerning an analyte. At least one catalytic agent is provided in a locale or vicinity of the interface. The catalytic agent, such as a proteinaceous agent or a non-proteinaceous, organic-metal agent, is sufficient to catalyze the degradation of reactive oxygen and/or nitrogen species that may be present in the vicinity of the interface. An analyte-sensing kit and a method of sensing an analyte are also described.

Claims

1. An analyte monitoring device, comprising a first electrode that functions as a working electrode, a second electrode that function as a counter electrode or a reference/counter electrode, and a substrate, wherein the electrodes and the substrate are positioned in a stacked configuration such that the electrodes are positioned substantially on top of each other with an insulator therebetween, and further, wherein at least a portion of the device is configured for positioning below a skin surface, the device further configured to generate an analyte related signal to communicate to an external device.

5. The device of claim 1 comprising a membrane.

6. The device of claim 5 wherein the membrane is formed in situ.

7. The device of claim 6 wherein the membrane limits the transport of mass to the sensor.

8. The device of claim 1 wherein the first and the second electrodes respectively include carbon and silver/silver chloride.

9. The device of claim 1, wherein the first electrode is positioned on the substrate, the insulator positioned on the first electrode, and the second electrode positioned on the insulator.

10. The device of claim 9 including a third electrode.

11. The device of claim 10, wherein the third electrode is positioned on an insulator that is positioned on the second electrode.

12. The device of claim 10 wherein the third electrode is a reference electrode.

2. The device of claim 1 comprising an analyte responsive enzyme.

3. The device of claim 2 wherein the enzyme is a glucose responsive enzyme

4. The device of claim 2 wherein the enzyme is a wired enzyme.

13. The device of claim 12, wherein the insulator is positioned on the counter electrode.

14. The sensor of claim 12 comprising an analyte responsive enzyme.

15. The device of claim 14 wherein the enzyme is disposed on the device.

16. The device of claim 12 comprising a membrane.

17. The device of claim 16 wherein the membrane is formed in situ.

18. The device of claim 12 wherein at least another portion of the first conducting layer is in fluid contact with an analyte of a patient.

12-1. A transcutaneous sensor, comprising:

a first layer;

a first conducting layer functioning as a working electrode, at least a portion of which is positioned in contact with at least a first portion of the first layer;

a second layer having a first surface and a second surface, at least a portion of the first surface positioned in contact with at least a first portion of the first conducting layer; and

a second conducting layer that functions as a counter electrode or a reference/counter electrode, at least a portion of which is positioned in contact with at least a portion of the second surface of the second layer, such that the first and second conducting layers are positioned in a stacked configuration with at least a portion of the second layer therebetween;

wherein at least a portion of the sensor is configured for positioning below a skin surface, the sensor further configured to generate an analyte related signal to communicate to an external device.

13-2. The sensor of claim 12 wherein the first and the second layers comprise nonconducting material.

19. A method, comprising:

providing a first electrode that functions as a working electrode;

providing a second electrode that function as a counter electrode or a reference/counter electrode;

providing a substrate;

positioning the first and second electrodes and the substrate in a stacked configuration such that the electrodes are positioned substantially on top of each other with an insulator therebetween;

positioning at least a portion of the device below a skin surface; and

generating an analyte related signal to communicate to an external device.

20. The method of claim 19 further including providing an analyte responsive enzyme.