Fiber Optic Probe

• US 20070225579A1
• Filed: 05/09/2005
• Published: 09/27/2007
• Est. Priority Date: 05/14/2004
• Status: Abandoned Application

• Current Assignee: Koninklijke Philips N.V.
• Original Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Inventors: Gijsbers, Geert, Neerken, Sieglinde, Van Beek, Michael, Lucassen, Gerard
• Application Number:
  US11/568,995
• Publication Number:
  US 20070225579A1
• Time in Patent Office: Days
• US Class Current: 600/310
• CPC Class Codes: G01J 3/44 Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry

Abstract

The present invention provides a spectroscopic system and in particular a fiber optic probe for in vivo detection of vulnerable atherosclerotic plaque inside the cardiovascular system of a patient. Detection of vulnerable plaque is based on a location dependent measurement of concentration levels of cardiac marker molecules flowing in the blood stream. Concentration level determination is preferably based on surface-enhanced Raman spectroscopic techniques providing sufficient sensitivity for determination of these concentration levels. Acquisition of spectroscopic data during moving of the fiber optic probe through the cardiovascular system with controlled velocity allows to precisely locate vulnerable plaque in the cardiovascular system.

Claims

1. A fiber optic probe (102) of a spectroscopic system comprising:

means for directing excitation radiation (140)into a volume of interest,

means for collecting return radiation (142) from the volume of interest,

means for inducing a surface-enhanced spectroscopic effect.

2. The fiber optic (102) probe according to claim 1, wherein the means for inducing the surface-enhanced spectroscopic effect comprising a thin metal coating (120), the thickness of the metal coating being in a range of nanometers.

3. The fiber optic probe (102) according to claim 2, wherein the thin metal coating (120) being adapted to adsorb marker molecules.

4. The fiber optic probe (102) according to claim 3, wherein the thin metal coating (120) further comprising a surface roughness being adapted for adsorbing of the marker molecules (130).

5. The fiber optic probe (102) according to claim 1, wherein the fiber optic probe being designed as a catheter being adapted to be inserted into a vascular system of a patient.

6. The fiber optic probe (102) according to claim 5, being further adapted to be moved through the vascular system of the patient.

7. The fiber optic probe (102) according to claim 1, further comprising a reflective element (121) being adapted as means for inducing the surface-enhanced spectroscopic effect.

8. A spectroscopic system (100) comprising:

a fiber optic probe (102) for directing excitation radiation (140) into a volume of interest and for collecting return radiation (142) from the volume of interest, wherein the fiber optic probe being coated with a thin metal coating (120) at its distal end,

a spectroscopic apparatus (110) being adapted to spectrally analyze the collected return radiation (142) and being adapted to be connected to a proximal end of the fiber optic probe (102).

9. The spectroscopic system (100) according to claim 8, further comprising:

means for moving the distal end of the fiber optic probe (102) through a vascular system of a patient,

means for correlating the collected return radiation (142) with a location of the distal end of the fiber optic probe (102).

10. A spectroscopic apparatus (110) of a spectroscopic system (100) having a fiber optic probe (102) for directing excitation radiation (140) into a volume of interest and for collecting return radiation (142) from the volume of interest, wherein the fiber optic probe being coated with a thin metal coating (120) at its distal end, the spectroscopic apparatus comprising:

coupling means for connecting the spectroscopic apparatus (110) with the proximal end of the fiber optic probe (102),

analyzing means being adapted to spectrally analyze the collected return radiation (142),

correlation means being adapted to correlate the collected return radiation with a location of the distal end of the fiber optic probe.

11. A computer program product for a spectroscopic system (100) having a fiber optic probe (102) and a spectroscopic apparatus (110), the computer program product comprising computer program means being adapted for:

moving of a distal end of the fiber optic probe (102) through a vascular system of a patient,

determining the location of the distal end of the fiber optic probe,

correlating the location of the distal end of the fiber optic probe with the collected return radiation (142).

12. A method of determining of cardiac marker concentration within a cardiovascular system of a patient, the method comprising the steps of:

collecting return radiation (142) from a volume of interest by a distal end of a fiber optic probe (102)

inducing a surface-enhanced spectroscopic effect by the distal end of a fiber optic probe (102),

spectrally analyzing the collected return radiation (142),

moving the distal end of the catheter during collection of return radiation,

correlating a location of the distal end of the fiber optic probe with the collected return radiation.