Treatment of prostate cancer, melanoma or hepatic cancer

  • US 20070244110A1
  • Filed: 04/14/2006
  • Published: 10/18/2007
  • Est. Priority Date: 04/14/2006
  • Status: Abandoned Application
First Claim
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1. A method of treating prostate cancer, melanoma or hepatic cancer in a subject in need thereof, said method comprising administering to said subject a therapeutically effective amount of the heterocyclic compound represented by Formula I:

  • or a pharmaceutically acceptable salt thereof, wherein, X represents C—

    R7 wherein R7 denotes hydrogen or a halogen;

    R1 and R2 independently represent hydrogen or a C1-C6 alkyl;

    R3 represents;

    an optionally substituted morpholino;

    an optionally substituted pyrrolydinyl;

    or a —

    NR10R11 group, wherein R10 and R11, independently denote a C1-C6 alkyl, a hydroxy C1-C6 alkyl, a morpholino with C1-C6 alkyl;

    R4 represents hydrogen, a C1-C6 alkyl, a C1-C6 alkoxy, a C1-C6 alkoxycarbonyloxy, amino, or hydroxyl;

    R5 represents hydrogen, a C1-C6 alkyl, a halogen, or hydroxyl;

    R6 represents;

    a C1-C6 alkyl;

    a hydroxy C1-C6 alkyl;

    a —

    CHnF3-n group wherein n denotes 1 or 2;



    NHR12, wherein R12 denotes hydrogen or a COR13 group, wherein R13 denotes hydrogen, a C1-C6 alkyl or a C1-C6 alkoxy.

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