Radiation Therapy and Medical Imaging Using Uv Emitting Nanoparticles

• US 20070274909A1
• Filed: 12/09/2004
• Published: 11/29/2007
• Est. Priority Date: 12/17/2003
• Status: Abandoned Application

• Current Assignee: Koninklijke Philips N.V.
• Original Assignee: Koninklijke Philips N.V.
• Inventors: Feldmann, Claus, Justel, Thomas
• Application Number:
  US10/596,440
• Publication Number:
  US 20070274909A1
• Time in Patent Office: Days
• US Class Current: 424/1.530
• CPC Class Codes: A61K 41/00 Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
• CPC Class Codes: A61K 47/6923 the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
• CPC Class Codes: A61K 47/6929 the form being a nanoparticle, e.g. an immuno-nanoparticle
• CPC Class Codes: A61K 49/0428 Surface-modified nanoparticles, e.g. immuno-nanoparticles
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: B82Y 5/00 Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

The invention relates to UV emitting nanoparticles for radiation therapy purposes. If the nanoparticles are brought indirectly or directly to the diseased tissue, excitation with high energy radiation leads to VUV or UV-C emission. This UV radiation is absorbed by the surrounding organic matrix, resulting in decomposition of the material. The nanoparticles can also be modified by attaching antibodies to the particles by chemical linking or coating. Preferably these antibodies bind specifically to the cell membrane of cancer cells leading to a localised destruction of diseased tissue with a high efficacy and a lower level of destruction of surrounding healthy tissue. Endoscopic detection of the UV emission can be used as a medical imaging technique to locate and study diseased tissue.

Claims

1. Nanoparticles for use in imaging or in radiation treatment of biological material, the nanoparticles comprising a VUV or UV-C emitting material which absorbs high energy radiation and emits VUV or UV-C radiation, said nanoparticles being conjugated to a bio-target specific agent.

2. Nanoparticles as claimed in claim 1, for use in radiation therapy.

3. Nanoparticles as claimed in claim 1, wherein the high energy radiation is X-rays.

4. Nanoparticles as claimed in claim 1, wherein said bio-target specific agents are antibodies or antibody fragments.

5. Nanoparticles as claimed in claim 4, wherein the antibodies or antibody fragments have a specificity for a diseased tissue.

6. Nanoparticles as claimed in claim 1, wherein the UV emitting material of the nanoparticles is provided with a covering layer.

7. Nanoparticles as claimed in claim 6, wherein the covering layer prevents hydrolysis of the UV emitting material.

8. Nanoparticles as claimed in claim 1, wherein the VUV or UV-C emitting material is one or more substances selected from the group:

-, M₂SiO₅;

X, MAlO₃;

X, M₃Al₅O₁₂;

X, MPO₄;

X, MBO₃;

X, MB₃O₆;

X with M=Y, La, Gd, Lu, and X=Pr, Ce, Bi, Nd or any of MM′

O₃;

X with M=Y, La, Gd, Lu, M′

=Y, La, Gd, Lu, Bi and X=Pr, Ce, Bi or any of MSO₄;

Z with M=Sr, Ca and Z=Nd, Pr, Ce, Pb or any of LuPO₄;

Nd, YPO₄;

Nd, LaPO₄;

Nd, LaPO₄;

Pr, LuPO₄;

Pr, YPO₄;

Pr, YPO₄;

Bi.

9. Nanoparticles as claimed in claim 1, wherein the VUV or UV-C emitting material is a trivalent phosphate.

10. Nanoparticles as claimed in claim 1, wherein the nanoparticles are doped with an activator.

11. Nanoparticles according to claim 10, wherein the activator has a decay time shorter than 100 ns.

12. Nanoparticles as claimed in claim 10, wherein said activator is Pr³⁺ or Nd³⁺.

25. A method of treatment of a human or an animal patient by:

providing nanoparticles according to claim 1, administering the nanoparticles to the patient, and irradiating the patient with high energy radiation.

13. The use of nanoparticles as an imaging agent or a radiation treatment agent, the nanoparticles comprising a VUV or UV-C emitting material which absorbs high energy radiation and emits VUV or UV-C radiation.

14. The use of claim 13, in the manufacture of an imaging agent or a radiation therapy agent.

15. The use as claimed in claim 13, wherein the high energy radiation is X-rays.

16. The use as claimed in claim 13, said nanoparticles being conjugated to a bio-target specific agent.

17. The use as claimed in claim 16, wherein said bio-target specific agents are antibodies or antibody fragments.

18. The use as claimed in claim 17, wherein the antibodies or antibody fragments have a specificity for the bio-target.

19. The use as claimed in claim 13, wherein the UV emitting material of the nanoparticles is provided with a covering layer.

20. The use as claimed in claim 19, wherein the covering layer prevents hydrolysis of said UV emitting material.

21. The use as claimed in claim 13, wherein the VUV or UV-C emitting material is one or more substances selected from the group:

M₂SiO₅;

X, MAlO₃;

X, M₃Al₅O₁₂;

X, MPO₄;

X, MBO₃;

X, MB₃O₆;

X with M=Y, La, Gd, Lu, and X=Pr, Ce, Bi, Nd or any of MM′

O₃;

X with M=Y, La, Gd, Lu, Bi, M′

=Y, La, Gd, Lu, and X=Pr, Ce, Bi or any of MSO₄;

Z with M=Sr, Ca and Z=Nd, Pr, Ce, Pb or any of LuPO₄;

Nd, YPO₄;

Nd, LaPO₄;

Nd, LaPO₄;

Pr, LuPO₄;

Pr, YPO₄;

Pr, YPO₄;

Bi.

22. The use as claimed in claim 13, wherein the UV emitting material is a trivalent phosphate.

23. The use as claimed in claim 13, wherein the nanoparticles are doped with an activator.

24. The use as claimed in claim 23, wherein said activator is Pr³⁺ or Nd³⁺.