Composition containing Vitamin D and phytoestrogens

• US 20070275940A1
• Filed: 04/27/2007
• Published: 11/29/2007
• Est. Priority Date: 03/21/2000
• Status: Abandoned Application

• Current Assignee: New Life Pharmaceuticals Incorporated
• Original Assignee: New Life Pharmaceuticals Incorporated
• Inventors: RODRIGUEZ, Gustavo
• Application Number:
  US11/741,597
• Publication Number:
  US 20070275940A1
• Time in Patent Office: Days
• US Class Current: 514/170
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/352 condensed with carbocyclic rings, e.g. methantheline cannabinoids A61K31/658
• CPC Class Codes: A61K 31/56 Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
• CPC Class Codes: A61K 31/565 not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
• CPC Class Codes: A61K 31/567 substituted in position 17 alpha, e.g. mestranol, norethandrolone
• CPC Class Codes: A61K 31/57 substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
• CPC Class Codes: A61K 31/59 Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 35/00 Antineoplastic agents

Abstract

The present invention relates to compositions and methods for preventing the development of epithelial ovarian cancer by administering compounds in an amount capable of regulating TGF-β expression in the ovarian epithelium and/or capable of optimally altering expression of other surrogate biomarkers identified by microarray technology. HRT and OCP regimens comprising such compositions and methods are disclosed.

Claims

1-33. -33. (canceled)

34. A composition comprising a phytoestrogen compound and a Vitamin D compound wherein the daily dosage of said Vitamin D compound is at least 2000 IU.

35. The composition of claim 34 wherein said phytoestrogen compound is at least 20 mg.

36. The composition of claim 35 wherein said dosage of said phytoestrogen compound is at least 50 mg.

37. The composition of claim 36 wherein said dosage of said phytoestrogen compound is at least 80 mg.

38. The composition of claim 37 wherein said dosage of said phytoestrogen compound is between 50 mg and 80 mg.

39. The composition of claim 34 wherein said phytoestrogen compound is an isoflavone.

40. The composition of claim 39 wherein the daily dosage of the isoflavone is at least 20 mg.

41. The composition of claim 40 wherein said dosage of the isoflavone is at least 50 mg.

42. The composition of claim 41 wherein said dosage of the isoflavone is at least 80 mg.

43. The composition of claim 41 wherein said dosage of the isoflavone is between 50 mg and 80 mg.

44. The composition of claim 34 wherein said phytoestrogen compound is a lignan.

45. The composition of claim 44 wherein the daily dosage of the lignan is at least 20 mg.

46. The composition of claim 45 wherein said dosage of the lignan is at least 50 mg.

47. The composition of claim 46 wherein said dosage of the lignan is at least 80 mg.

48. The composition of claim 46 wherein said dosage of the lignan is between 50 mg and 80 mg.

49. The composition of claim 34 wherein said phytoestrogen compound is a coumestan.

50. The composition of claim 49 wherein the daily dosage of the coumestan is at least 20 mg.

51. The composition of claim 50 wherein said dosage of the coumestan is at least 50 mg.

52. The composition of claim 51 wherein said dosage of the coumestan is at least 80 mg.

53. The composition of claim 51 wherein said dosage of the coumestan is between 50 mg and 80 mg.

54. The composition of claim 34 wherein the daily dosage of said Vitamin D compound is at least 4000 IU.

55. The composition of claim 54 wherein said daily dosage of the phytoestrogen product is at least 50 mg.

56. The composition of claim 54 wherein said dosage of the phytoestrogen product is at least 80 mg.

57. The composition of claim 54 wherein said dosage of the phytoestrogen product is between 50 mg and 80 mg.

58. The composition of claim 34 wherein said dosage of the Vitamin D compound is 2000 IU.

59. The composition of claim 34 wherein said dosage of the Vitamin D compound is 4000 IU.

60. The composition of claim 34 wherein said dosage of the Vitamin D compound between 2000 IU and 4000 IU.

61. The composition of claim 34 wherein said Vitamin D compound is Vitamin D₂ (ergocalciferol).

62. The composition of claim 34 wherein said Vitamin D compound is Vitamin D₃ (cholecalciferol).

63. A composition comprising an isoflavone compound and Vitamin D₃ (cholecalciferol) wherein the daily dosage of said Vitamin D₃ compound is at least 2000 IU.

64. The composition of claim 63 wherein the daily dosage of the isoflavone product is at least 20 mg.

65. The composition of claim 64 wherein said dosage of the isoflavone product is at least 50 mg.

66. The composition of claim 65 wherein said dosage of the isoflavone product is at least 80 mg.

67. The composition of claim 65 wherein said dosage of the isoflavone product is between 50 mg and 80 mg.

68. The composition of claim 63 wherein the daily dosage of said Vitamin D₃ compound is at least 4000 IU.

69. The composition of claim 68 wherein said daily dosage of the isoflavone product is at least 50 mg.

70. The composition of claim 69 wherein said dosage of the isoflavone product is at least 80 mg.

71. The composition of claim 69 wherein said dosage of the isoflavone product is between 50 mg and 80 mg.

72. The composition of claim 71 wherein said dosage of the Vitamin D compound is 2000 IU.

73. The composition of claim 72 wherein said dosage of the Vitamin D compound is 4000 IU.