Coatable transdermal delivery microprojection assembly
First Claim
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1. A transdermal delivery assembly, comprising:
- a microprojection member having top and bottom surfaces and a plurality of stratum corneum-piercing microprojections that project from said bottom surface of said microprojection member; and
a retainer having first and second ends and a central opening;
wherein said microprojection member is secured to said retainer within said central opening and wherein said microprojection member is positioned adjacent said first end of said retainer so that at least a portion of said microprojections extend beyond a plane formed by said first end of said retainer.
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Abstract
The present invention is a transdermal delivery microprojection assembly that includes a microprojection member secured to a retainer adapted for use with an impact applicator wherein at least a portion of the microprojections extend beyond a plane formed by the end of the retainer. The configuration allows a biocompatible coating containing a biologically active agent to be applied to the microprojection member after it is mounted on the retainer. The present invention minimizes the number of manufacturing steps that must be carried out under aseptic conditions to maintain sterility of the assembly after the coating is applied to the microprojection member.
65 Citations
23 Claims
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1. A transdermal delivery assembly, comprising:
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a microprojection member having top and bottom surfaces and a plurality of stratum corneum-piercing microprojections that project from said bottom surface of said microprojection member; and
a retainer having first and second ends and a central opening;
wherein said microprojection member is secured to said retainer within said central opening and wherein said microprojection member is positioned adjacent said first end of said retainer so that at least a portion of said microprojections extend beyond a plane formed by said first end of said retainer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A method for producing a transdermal delivery assembly, comprising the steps of:
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providing a microprojection member having top and bottom surfaces and a plurality of stratum corneum-piercing microprojections that project from said bottom surface of said microprojection member;
providing a retainer having first and second ends and a central opening; and
securing said microprojection member to said retainer within said central opening to form said transdermal delivery assembly wherein said microprojection-member is positioned adjacent said first end of said retainer so that at least a portion of said microprojections extend beyond a plane formed by said first end of said retainer. - View Dependent Claims (18, 19, 20, 21, 22, 23)
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Specification