Apparatus and method for cell migration assays
First Claim
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1. A method of detecting cell migration, the method comprising:
- providing a plurality of cells on a substrate comprising a plurality of detection units, wherein each of said cells is disposed over at least one of said detection units; and
detecting cellular movement of at least one of said cells.
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Abstract
The present invention is directed to a method and apparatus for detecting and analyzing cell migration. More specifically, the present invention is directed to novel technology for analyzing cellular movement, including whole cell migration and subcellular component movement. Cells are distributed onto a substrate and monitored for migration or movement. According to one embodiment, when a labelled cell or portion of a cell passes over one of the delineations between detection units, such as individual fibers in a fiber optic bundle, the label causes a large intensity increase, which stays for a given “residence time” until the cell departs from the detection unit.
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39 Claims
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1. A method of detecting cell migration, the method comprising:
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providing a plurality of cells on a substrate comprising a plurality of detection units, wherein each of said cells is disposed over at least one of said detection units; and
detecting cellular movement of at least one of said cells. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A composition for detection of cellular migration, the composition comprising:
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a substrate comprising a plurality of detection units; and
a plurality of cells distributed on said substrate such that each of said cells is disposed over at least one of said detection units. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39)
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Specification