Drug delivery system

• US 20080045925A1
• Filed: 06/18/2007
• Published: 02/21/2008
• Est. Priority Date: 06/19/2006
• Status: Abandoned Application

• Current Assignee: Monterey Devices, Inc. (Bausch Health Cos., Inc.)
• Original Assignee: Monterey Devices, Inc. (Bausch Health Cos., Inc.)
• Inventors: Davenport, Kenneth, Stepovich, Matthew, Falkel, Michael
• Application Number:
  US11/820,208
• Publication Number:
  US 20080045925A1
• Time in Patent Office: Days
• US Class Current: 604/518
• CPC Class Codes: A61M 2205/3653 by Joule effect, i.e. electric resistance
• CPC Class Codes: A61M 5/14566 with a replaceable reservoir for receiving a piston rod of the pump
• CPC Class Codes: A61M 5/16827 controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths infusion of multiple fluids without using a controller A61M5/1407
• CPC Class Codes: A61M 5/445 the media being heated in the reservoir, e.g. warming bloodbags

Abstract

System for the delivery of drugs from sealed cartridges provide for versatile and convenient delivery of the drugs. The system can be designed to deliver drugs from a plurality of cartridges with delivery through a manifold that connects to the plurality of cartridges. In some embodiments, the system mediates the heating of the drug such that it can be delivered at a temperature more closely approximating body temperature. In some embodiments, the composition of one cartridge is used to adjust the pH of the composition of the resulting mixture to achieve a desirable blended drug. The systems and procedures are particularly advantageous for the delivery of dental anesthetics.

Claims

1. A method for the delivery of multiple units of a drug from sealed cartridges to a patient, the method comprising selectively delivering the drug from a plurality of individually sealed first cartridges using a motor to advance a plug within a cartridge to drive the drug from the cartridge, the first cartridges being positioned on a stationary housing, wherein the drug from the first cartridges flows through a manifold fluidly connected to flexible tubing, wherein the flexible tubing is fluidly connected to a delivery component that delivers the drug to the patient and wherein the drug flows from the first cartridges to the delivery component through a sealed fluid path.

2. The method of claim 1 wherein the drug is simultaneously driven from the plurality of first cartridges.

3. The method of claim 1 wherein the delivery component comprises a hypodermic needle and wherein the delivering comprises performing a hypodermic injection.

4. The method of claim 1 wherein the plurality of first cartridges are supported within a cartridge holder and wherein the manifold is embedded within the cartridge holder.

5. The method of claim 1 further comprising aspirating liquid from the patient through reversing the movement of the plug.

6. The method of claim 1 wherein an at least one second cartridge comprises a composition different from the drug in the first cartridge and wherein the composition is delivered to the delivery component through the manifold.

7. The method of claim 1 further comprising a controller that can be programmed to deliver a volume of the drug to the patient.

8. The method of claim 1 wherein the drug comprises anesthetic, wherein at least one second cartridge comprises an alkaline composition, and wherein a mixture of the drug and the alkaline composition is formed in the manifold to raise the pH of the drug.

9. The method of claim 1 further comprising warming the fluid before it is delivered from the delivery component.

10. A drug delivery system comprising:

a housing comprising at least one motor operably connected to a plurality of pistons;

a cartridge holder comprising a plurality of positioning slots configured to hold a fluid cartridge in an alignment to be engaged by one of the pistons when the piston is translated;

a plurality of transfer tubes comprising a first end configured to engage and enter a sealed cartridge at a positioning slot, wherein at least one transfer tube comprises a displaceable cap covering the first end of the transfer tube;

a manifold comprising an output port and a plurality of channels wherein a channel is fluidly connected with a transfer tube and wherein the manifold has a configuration in which flows from the channels combine while having a fluid connection to the output port;

flexible tubing comprising a first end and a second end, wherein the first end is fluidly connected to the output port of the manifold; and

a patient delivery component comprising a fluid outlet, the patient delivery component being fluidly connected with the second end of the flexible tubing.

11. The drug delivery system of claim 10 wherein the manifold is embedded within the cartridge holder.

12. The drug delivery system of claim 10 wherein the transfer tubes are integral with the manifold.

13. The drug delivery system of claim 10 wherein the cartridge holder is releasably engaged with the housing.

14. The drug delivery system of claim 10 further comprising a controller comprising input controls wherein the controller is operably connected to the at least one motor to control the function of the at least one motor and wherein the at least one motor is operably connected to a drive that simultaneously propels the pistons.

15. The drug delivery system of claim 10 further comprising a controller comprising input controls wherein the controller is operably connected to the at least one motor to control the function of the at least one motor and wherein the at least one motor is operably connected to a drive that propels the pistons in a selected pattern wherein the pistons are not driven at equal rates.

16. The drug delivery system of claim 15 wherein the at least one motor comprises at least two motors that drive different pistons.

17. The drug delivery system of claim 16 wherein the at least two motors have adjustable speeds to provide the capability to propel the different pistons at different speeds.

18. The drug delivery system of claim 10 further comprising a plurality of cartridges comprising drugs, wherein each cartridge is loaded at a positioning slot.

19. The drug delivery system of claim 10 further comprising a plurality of cartridges comprising anesthetic, wherein each cartridge is loaded at a positioning slot.

20. The drug delivery system of claim 10 wherein the piston is configured to move a plug within a cartridge in a forward or reverse direction and wherein the controller is programmed to withdraw the piston a select amount to provide for aspiration.

21. The drug delivery system of claim 10 further comprising at least one heating element configured to heat at least one component of the system.

22. The drug delivery system of claim 10 further comprising a plurality of cartridges wherein at least one cartridge comprises a first drug and at least one cartridge comprises a second drug.

23. The drug delivery system of claim 10 further comprising a plurality of cartridges wherein at least one cartridge comprises an anesthetic and at least one cartridge comprises an alkalinizing composition.

24. A drug delivery system comprising:

a housing comprising at least one motor operably connected to at least one piston;

a cartridge holder having at least one positioning slot configured to hold a cartridge;

at least one transfer tube configured to enter a sealed cartridge to establish a flow passage to an output port;

flexible tubing having a first end and a second end wherein the first end if fluidly connected to the output port;

a patient delivery component comprising a fluid outlet, the patient delivery component being fluidly connected with the second end of the flexible tubing; and

a heating element, wherein the heating element is configured to heat at least one component of the system.

25. The drug delivery system of claim 24 wherein the housing comprises a plurality of positioning slots wherein each positioning slot is configured to hold a drug cartridge for the delivery of drugs from the cartridge.

26. The drug delivery system of claim 24 wherein the cartridge holder is removably connected to the housing.

27. A method for the delivery of a mixture of drugs to a patient, the method comprising delivering a mixture of different drugs from a manifold connected to a plurality of cartridges comprising at least a first cartridge and a second cartridge, which cartridges contain different drugs and are positioned on a stationary housing, using a motor to move a plug within the first cartridge to drive the drug from the first cartridge to the manifold wherein the manifold is fluidly connected to flexible tubing and wherein the flexible tubing is fluidly connected to a delivery component to deliver the mixture.

28. The method of claim 27 wherein the motor moves a plug within the second cartridge to drive the drug from the second cartridge to the manifold.

29. The method of claim 27 further comprising a second motor that moves a plug in the second cartridge to drive the drug from the second cartridge to the manifold.

30. The method of claim 27 wherein the first cartridge comprises an anesthetic and the second cartridge comprises an alkalinizing substance.

31. The method of claim 30 further comprising a second motor that moves a plug in the second cartridge positioned on the stationary housing to drive the alkalinizing substance from the second cartridge to the manifold at a selectable rate to achieve a desired pH of the mixture.