Modified Human Growth Hormone
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Accused Products
Abstract
Modified growth hormone polypeptide and uses thereof are provided.
110 Citations
90 Claims
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1-77. -77. (canceled)
- 78. A hormone composition comprising a growth hormone (GH) linked via an oxime bond to a PEG.
- 85. A method of treating a patient with a composition comprising a growth hormone linked via an oxime bond to a PEG.
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90. A hormone composition comprising hGH linked via an oxime bond to a PEG and a pharmaceutically acceptable carrier, wherein, when the formulation is administered through subcutaneous injection in a dose of between 0.05 mg/kg to 1 mg/kg a mean plasma concentration profile having a mean AUC∞
- of about 362,443 ngXh/mL±
20%, and a mean Cmax of about 4,977 ng/mL±
20% is achieved, and wherein the formulation is effective to increase tibial length, body weight, or both.
- of about 362,443 ngXh/mL±
Specification