METHOD AND APPARATUS FOR ANALYTE MEASUREMENTS IN THE PRESENCE OF INTERFERENTS
First Claim
1. A method for estimating a concentration of an analyte in a sample from a measurement of the sample, the method comprising:
- determining, based on the measurement, a list of one or more possible interferents to the measurement of the analyte in the sample;
calculating, for each one of the possible interferents on the list, a single interferent analyte concentration based on the presumed presence in the sample of the one interferent and no other interferents from the list; and
determining an estimated analyte concentration based at least in part on the single interferent analyte concentrations.
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Abstract
Method and apparatus are described that permit an analyte concentration to be estimated from a measurement in the presence of compounds that interfere with the measurement. The method reduces the error in the analyte concentration in the presence of interferents. The method includes the use of a set of measurements obtained for a large population having a range of known analyte and interfering compound concentrations. From a sample measurement, which may or may not be one of the population, interferents likely to be present are identified, and a calibration coefficient is calculated. The calibration coefficient may be applied to the measurement to estimate the analyte concentration. In some implementations, the calibration coefficient may be determined as a weighted average of single interferent calibration coefficients. In some embodiments, the sample measurement includes a spectroscopic measurement.
54 Citations
35 Claims
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1. A method for estimating a concentration of an analyte in a sample from a measurement of the sample, the method comprising:
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determining, based on the measurement, a list of one or more possible interferents to the measurement of the analyte in the sample; calculating, for each one of the possible interferents on the list, a single interferent analyte concentration based on the presumed presence in the sample of the one interferent and no other interferents from the list; and determining an estimated analyte concentration based at least in part on the single interferent analyte concentrations. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. An apparatus for estimating a concentration of an analyte in a sample from a measurement of the sample, the apparatus comprising:
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means for determining, based on the measurement, a list of one or more possible interferents to the measurement of the analyte in the sample; means for calculating, for each one of the interferents on the list, a single interferent analyte concentration based on the presumed presence in the sample of the one interferent and no other interferents from the list; and means for determining an estimated analyte concentration based at least in part on the single interferent analyte concentrations. - View Dependent Claims (18, 19, 20, 21)
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22. An analyte detection system comprising:
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a sensor system configured to provide information relating to a measurement of an analyte in a sample; and a processor system configured to execute stored program instructions such that the analyte detection system; determines, based on the measurement, a list of one or more possible interferents to the measurement of the analyte in the sample; calculates, for each one of the interferents on the list, a single interferent analyte concentration based on the presumed presence in the sample of the one interferent and no other interferents from the list; and determines an estimated analyte concentration based at least in part on the single interferent analyte concentrations. - View Dependent Claims (23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35)
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Specification