Drug delivery and method having coated microprojections incorporating vasoconstrictors
First Claim
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1. A device for transdermally delivering a biologically active agent, comprising:
- a member having a plurality of stratum corneum-piercing microprotrusions; and
a coating disposed on said member, said coating including a biologically active agent and a vasoconstrictor.
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Abstract
A device and method are provided for percutaneous transdermal delivery of a biologically active agent. The coating formulation containing the biologically active agent and a vasoconstrictor is applied to the skin piercing elements using known coating techniques and then dried. The device is applied to the skin of a living animal, causing the microprojections to pierce the stratum corneum and to deliver an effective dose of the biologically active agent and vasoconstrictor to the animal.
33 Citations
30 Claims
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1. A device for transdermally delivering a biologically active agent, comprising:
- a member having a plurality of stratum corneum-piercing microprotrusions; and
a coating disposed on said member, said coating including a biologically active agent and a vasoconstrictor. - View Dependent Claims (2, 3, 4, 5, 6)
- a member having a plurality of stratum corneum-piercing microprotrusions; and
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7. (canceled)
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8. (canceled)
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9. A device for transdermally delivering a biologically active agent and a vasoconstrictor, comprising:
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a member having a plurality of stratum corneum-piercing microprotrusions; and a dry coating disposed on at least one of said plurality of stratum corneum-piercing microprotrusions, said coating including a biologically active agent and a vasoconstrictor. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. (canceled)
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21. A method of making a device for transdermally delivering a biologically active agent and a vasoconstrictor, the method comprising:
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providing a member having a plurality of stratum corneum-piercing microprotrusions, said microprotrusions having a length of less than 1000 microns; applying an aqueous solution of a biologically active agent and a vasoconstrictor onto the member; and drying said applied aqueous solution to form a dry agent-containing coating on said member. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28)
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29. A method of making a device for transdermally delivering a biologically active agent and a vasoconstrictor, the method comprising:
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providing a sheet member; etching a microprojection array on said sheet member to form a plurality of microprojections; bending said plurality of microprojections whereby said plurality of microprojections project from a plane of said sheet member; coating at least a first microprojection of said plurality of microprojections with an aqueous solution containing a biological active agent and a vasoconstrictor; and drying said applied aqueous solution to form a dry agent containing coating on said first microprojection.
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30-39. -39. (canceled)
Specification