Implantable Addressable Segmented Electrodes

• US 20080255647A1
• Filed: 12/22/2005
• Published: 10/16/2008
• Est. Priority Date: 12/22/2004
• Status: Abandoned Application

• Current Assignee: Proteus Digital Health, Inc. (Otsuka Holdings Company Limited)
• Original Assignee: Proteus Digital Health, Inc. (Otsuka Holdings Company Limited)
• Inventors: Zdeblick, Mark, Thompson, Todd, Colliou, Olivier, Costello, Benedict J., Jensen, Marc, Savage, George M., Frank, Jeremy, Lei, Dino
• Application Number:
  US11/793,904
• Publication Number:
  US 20080255647A1
• Time in Patent Office: Days
• US Class Current: 607/119
• CPC Class Codes: A61N 1/05 for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence

Abstract

Implantable addressable segmented electrode devices, as well as methods for making and using the same, are provided. The subject devices include segmented electrode structures made up of an integrated circuit electrically coupled to two or more electrodes, where each electrode can be individually activated. Also provided are implantable devices and systems, as well as kits containing such devices and systems or components thereof, which include the segmented electrode structures.

Claims

1. An implantable addressable segmented electrode structure comprising:

an integrated circuit; and

two or more electrodes coupled to said integrated circuit, wherein each of said electrodes is individually addressable.

2. The implantable addressable segmented electrode structure according to claim 1, wherein said integrated circuit is electrically coupled to at least one elongated conductive member in a medical carrier.

3. The implantable addressable segmented electrode structure according to claim 2, wherein said integrated circuit is electrically coupled to a single elongated conductive member.

4. The implantable addressable segmented electrode structure according to claim 2, wherein said integrated circuit is electrically coupled to two elongated conductive members.

5. The implantable addressable segmented electrode structure according to claim 1, wherein said integrated circuit is less than about 1 mm from said electrodes.

6. The implantable addressable segmented electrode structure according to claim 1, wherein said integrated circuit is less than about 20 mm from said electrodes.

7. The implantable addressable segmented electrode structure according to claim 1, wherein said integrated circuit comprises said electrodes.

8. The implantable addressable segmented electrode structure according to claim 1, wherein said electrodes are circumferentially arranged around said integrated circuit.

9. The implantable addressable segmented electrode structure according to claim 8, wherein said electrodes are substantially aligned.

10. The implantable addressable segmented electrode structure according to claim 8, wherein said electrodes are staggered.

11. The implantable addressable segmented electrode structure according to claim 1, wherein said structure comprises electrodes that are interdigitated.

12. The implantable addressable segmented electrode structure according to claim 1, wherein said structure comprises electrodes of at least two different sizes.

13. The implantable addressable segmented electrode structure according to claim 1 wherein said structure comprises electrodes of about the same size.

14. The implantable addressable segmented electrode structure according to claim 1, wherein said structure comprises four electrodes.

15. The implantable addressable segmented electrode structure according to claim 1, wherein said structure comprises three electrodes.

16. The implantable addressable segmented electrode structure according to claim 1, wherein said structure is dimensioned to fit within a lead.

17. The implantable addressable segmented electrode structure according to claim 1, wherein each electrode has a surface area ranging from about 0.1 mm² to about 15 mm².

18. The implantable addressable segmented electrode structure according to claim 1, wherein each electrode has a surface area ranging from about 0.5 mm² to about 10 mm².

19. The implantable addressable segmented electrode structure according to claim 1, wherein each electrode has a surface area that is about 1.3 mm².

20. The implantable addressable segmented electrode structure according to claim 2, wherein integrated circuit, electrodes and at least one elongated conductive member are electrically coupled to each other in a manner that imparts fatigue resistance to said lead assembly.

21. The implantable addressable segmented electrode structure according to claim 20, wherein at least two of said integrated circuit, electrodes and elongated conductive member are electrically coupled to each other in a manner that minimizes mechanical stress on said structure.

22. The implantable addressable segmented electrode structure according to claim 20, wherein at least two of said integrated circuit, electrodes and elongated conductive member are conductively connected to each other by a flexible conductive member.

23. The implantable addressable segmented electrode structure according to claim 20, wherein at least two of said integrated circuit, electrodes and elongated conductive member are conductively connected to each other by a liquid member.

24. The implantable addressable segmented electrode structure according to claim 20, wherein at least two of said integrated circuit, electrodes and elongated conductive member are conductively connected to each other by a coil conductive member.

25. The implantable addressable segmented electrode structure according to claim 20, wherein at least two of said integrated circuit, electrodes and elongated conductive member are conductively connected to each other by a spherical conductive member.

26. The implantable addressable segmented electrode structure according to claim 1, wherein said electrodes have a curved configuration.

27. The implantable addressable segmented electrode structure according to claim 1, wherein said electrodes are flexible.

28. The implantable addressable segmented electrode structure according to claim 27, wherein said electrodes comprises one or more hairpin turns.

29. The implantable addressable segmented electrode structure according to claim 1, wherein said electrodes have a helical configuration.

30. The implantable addressable segmented electrode structure according to claim 1, wherein said integrated circuit comprises at least one through hole.

31. The implantable addressable segmented electrode structure according to claim 30, wherein said integrated circuit comprises at least two through holes.

32. The implantable addressable segmented electrode structure according to claim 30, wherein said integrated circuit has a non-rectangular configuration.

33. The implantable addressable segmented electrode structure according to claim 32, wherein said integrated circuit has a curvilinear configuration.

34. The implantable addressable segmented electrode structure according to claim 33, wherein said integrated circuit is disc-shaped.

35. The implantable addressable segmented electrode structure according to claim 1, wherein said integrated circuit is a hermetically sealed integrated circuit.

36. The implantable addressable segmented electrode structure according to claim 35, wherein said hermetically sealed integrated circuit comprises:

an in vivo corrosion resistant integrated circuit holder having at least one feedthrough;

at least one integrated circuit present in said holder; and

a sealing layer;

wherein said sealing layer and holder are configured to define a hermetically sealed volume in which said at least one integrated circuit is present.

37. The implantable addressable segmented electrode structure according to claim 1, wherein said structure is present in a lead.

38. The implantable addressable segmented electrode structure according to claim 37, wherein said lead has a circular cross-section.

39. The implantable addressable segmented electrode structure according to claim 37, wherein said lead has a oval cross-section.

40. The implantable addressable segmented electrode structure according to claim 37, wherein said lead has a flattened cross-section.

41. The implantable addressable segmented electrode structure according to claim 37, wherein said lead is a cardiac pacing lead.

42. The implantable addressable segmented electrode structure according to claim 2, wherein said elongated conductive member is electrically coupled to at least one control unit.

43. The implantable addressable segmented electrode structure according to claim 42, wherein said control unit is present in a pacemaker can.

82. The implantable addressable segmented electrode structure according to claim 1, wherein said structure is dimensioned to fit within an implant.

83. The implantable addressable segmented electrode structure according to claim 36, wherein said structure is present in an implant.

84. The implantable addressable segmented electrode structure according to claim 37, wherein said lead is a cardiac pacing lead.

85. The implantable addressable segmented electrode structure according to claim 2, wherein said elongated conductive member is electrically coupled to at least one control unit.

86. The implantable addressable segmented electrode structure according to claim 85, wherein said control unit is present in a pacemaker can.

87. An implantable medical device comprising at least one implantable addressable segmented electrode structure according to claim 1.

88. The implantable medical device according to claim 87, wherein said device is present in an Implant.

89. The implantable medical device according to claim 87, wherein said device is present in a lead.

90. The implantable medical device according to claim 89, wherein said lead is a cardiovascular lead.

91. The implantable medical device according to claim 89, wherein said lead is a left ventricular lead.

92. The implantable medical device according to claim 89, wherein said lead is an epicardial lead.

93. The implantable medical device according to claim 87, wherein said device is a neurological device.

94. The implantable medical device according to claim 87, wherein said device is a muscular device.

95. The implantable medical device according to claim 87, wherein said device is a gastrointestinal device.

96. The implantable medical device according to claim 87, wherein said device is a skeletal device.

97. The implantable medical device according to claim 87, wherein said device is a pulmonary device.

98. The implantable medical device according to claim 87, wherein said device is an opthalmic device.

99. The implantable medical device according to claim 87, wherein said device is an auditory device.

100. The implantable medical device according to claim 87, wherein said structure is electrically coupled to at least one elongated conductive member.

101. The implantable medical device according to claim 100, wherein said at least one conductive member is electrically coupled to a control unit.

102. The implantable medical device according to claim 101, wherein said control unit is present in a pacemaker can.

103. The implantable medical device according to claim 102, wherein said device is a cardiovascular pacing device.

104. A method comprising:

implanting an implantable medical device according to claim 97 into a subject; and

using said addressable segmented electrode structure of said implanted medical device.

105. The method according to claim 104, wherein said using comprises activating at least one of said electrodes of said structure to deliver electrical energy to said subject.

106. The method according to claim 105, wherein at least a first of said electrodes is connected to a first conductive member and a second of said electrodes is connected to a second conductive member.

107. The method according to claim 105, wherein said method comprises not activating at least one of said electrodes.

108. The method according to claim 107, wherein said method comprises activating only one of said electrodes.

109. The method according to claim 104, wherein said method further comprises determining which of said electrodes to activate.

110. The method according to claim 104, wherein said method further comprises sequentially activating said electrodes.

111. The method according to claim 109, wherein said method comprises minimizing power consumption.

112. The method according to claim 104, wherein said method comprises activating said electrodes in manner sufficient to not stimulate the phrenic nerve.

113. The method according to claim 104, wherein said using comprises activating at least one of said electrodes of said structure to sense electrical potential in said subject.

114. The method according to claim 113, wherein at least a first of said electrodes is connected to a first conductive member and a second of said electrodes is connected to a second conductive member.

115. The method according to claim 114, wherein said method comprises sensing conduction velocity.

116. A system comprising:

an implantable addressable segmented electrode structure according to claim 1; and

a control unit.

117. The system according to claim 116, wherein said structure and control unit are electrically coupled by at least one elongated conductive member.

118. The system according to claim 117, wherein said structure is present in a lead.

119. The system according to claim 118, wherein said lead is a cardiovascular lead.

120. The system according to claim 116, wherein said control unit is a pacemaker can.

121. A kit comprising:

an implantable addressable segmented electrode structure according to claim 1; and

a control unit.

122. The kit according to claim 121, wherein said kit further includes an elongated conductive member.

123. The kit according to claim 122, wherein said structure is present in a lead.

124. The kit according to claim 123, wherein said lead is a cardiovascular lead.

125. The kit according to claim 121, wherein said control unit is present in a pacemaker can.

15B. B. (canceled)

36B. B. (canceled)

44-81. -81. (canceled)