INTRAMEDULLARY ACCESS OR INFUSION DEVICES

• US 20080287910A1
• Filed: 05/13/2008
• Published: 11/20/2008
• Est. Priority Date: 05/14/2007
• Status: Active Grant

• Current Assignee: Everest Holdings LLC
• Original Assignee: Applied Medical Research
• Inventors: PICHA, George J.
• Granted Patent: US 7,833,204 B2
• Time in Patent Office: Days
• US Class Current: 604/507
• CPC Class Codes: A61B 17/3472 for bones, e.g. intraosseus injections
• CPC Class Codes: A61M 2210/02 Bones
• CPC Class Codes: A61M 39/0208 Subcutaneous access sites for injecting or removing fluids transcutaneous access sites A61M39/0247; implantable infusion devices A61M5/14276
• CPC Class Codes: A61M 39/04 having pierceable self-sealing members

Abstract

Intramedullary access or infusion devices that includes a tubular conduit having a distal end and a proximal end with a length sufficient to pass through the cortical region to the cancellous region of a bone; a flange circling the outside of the proximal end of the conduit; and a penetrable diaphragm positioned within the tubular conduit, are described. The devices may be placed in bone and later used, for example, as a site for administering a pharmacologically active agent.

Claims

1. An intramedullary access device, comprising:

a tubular conduit having a distal end and a proximal end with a length sufficient to pass through the cortical region to the cancellous region of a bone;

a flange circling the outside of the proximal end of the conduit; and

a penetrable diaphragm positioned within the tubular conduit.

2. The intramedullary access device of claim 1, wherein the outside of the tubular conduit includes surface texturing.

3. The intramedullary access device of claim 1, wherein the outside of the tubular conduit includes threading.

4. The intramedullary access device of claim 3, wherein the threading comprises micropillars.

5. The intramedullary access device of claim 1, wherein the length of the tubular conduit is from about 1 mm to about 10 mm.

6. The intramedullary access device of claim 1, wherein the penetrable diaphgram comprises an elastomer.

7. The intramedullary access device of claim 1, wherein the device further comprises a sensor.

8. The intramedullary access device of claim 1, wherein the device comprises a magnetic material.

17. A method of intramedullary drug delivery comprising:

detecting an intramedullary access device according to claim 1 in the bone of a patient;

inserting a needle through the penetrable diaphragm of the intramedullary access device; and

administering a drug through the intramedullary access device into the cancellous bone of the patient.

9. An intramedullary infusion device, comprising:

a tubular conduit having a distal end and a proximal end with a length sufficient to pass through the cortical region and extend into the cancellous region of a bone;

wherein the tubular conduit is closed at the distal end;

a flange circling the outside of the proximal end of the conduit;

a penetrable diaphragm positioned within the tubular conduit;

one or more outlet openings positioned along the tubular conduit in the region that will extend into cancellous bone; and

a compressible member positioned over the outlet openings at the distal end of the tubular conduit.

10. The intramedullary infusion device of claim 9, wherein the outlet openings are positioned on outlet structures that extend beyond the surface of the tubular conduit.

11. The intramedullary infusion device of claim 9, wherein the compressible member comprises an elastomer.

12. The intramedullary infusion device of claim 9, wherein the compressible member comprises a spring-loaded diaphragm.

13. The intramedullary infusion device of claim 9, wherein the outside of the tubular conduit includes surface texturing.

14. The intramedullary infusion device of claim 9, wherein the outside of the tubular conduit includes threading.

15. The intramedullary infusion device of claim 14, wherein the threading comprises micropillars.

16. The intramedullary infusion device of claim 9, wherein the device further comprises a sensor.

18. A method of intramedullary drug delivery comprising:

detecting an intramedullary infusion device according to claim 9 in the bone of a patient;

applying pressure to the compressible member of the intramedullary infusion device to expose an outlet opening; and

administering a drug through the intramedullary infusion device into the cancellous bone of the patient.