Tissue Ablation by Shear Force for Sampling Biological Fluids and Delivering Active Agents
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Accused Products
Abstract
A shear device for use in transporting a molecule through a mammal'"'"'s mammalian barrier membrane of at least one layer of cells includes a sheet containing an opening(s) and a shear member(s). The sheet is configured for contacting the mammalian barrier membrane (e.g., human skin) and the shear member is configured for ablating a portion of the mammalian barrier membrane forced through the opening(s). This ablating is accomplished by movement of the shear member(s) over the sheet and the opening(s). The ablation of the portion of the mammalian barrier membrane is such that a driving force can be employed to transport the molecule therethrough.
114 Citations
36 Claims
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1-23. -23. (canceled)
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24. A shear device for use in transporting a molecule through a mammal'"'"'s mammalian barrier membrane of at least one layer of cells comprising:
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a sheet containing at least one opening, the sheet configured for contacting a mammalian barrier membrane; and at least one shear member configured for ablating a portion of the mammalian barrier membrane forced through the at least one opening, the ablating accomplished by movement of the at least one shear member over the sheet and the at least one opening; wherein the portion of the mammalian barrier membrane is ablated such that a driving force can be employed to transport the molecule therethrough. - View Dependent Claims (31, 32, 33, 34, 35, 36)
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Specification