BACTERIAL EXTRACTS CULTURED IN THERMAL WATERS FOR THE TREATMENT OF DRY SKIN

• US 20090022819A1
• Filed: 07/17/2008
• Published: 01/22/2009
• Est. Priority Date: 07/17/2007
• Status: Abandoned Application

• Current Assignee: L'Oreal SA
• Original Assignee: L'Oreal SA
• Inventors: GUENICHE, AUDREY, BRETON, LIONEL
• Application Number:
  US12/175,072
• Publication Number:
  US 20090022819A1
• Time in Patent Office: Days
• US Class Current: 424/717
• CPC Class Codes: A61K 35/08 Mineral waters; Sea water
• CPC Class Codes: A61K 35/74 Bacteria therapeutic use of a bacterial protein A61K38/00
• CPC Class Codes: A61K 8/9728 Fungi, e.g. yeasts
• CPC Class Codes: A61K 8/99 from microorganisms other than algae or fungi, e.g. protozoa or bacteria
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/08 Antiseborrheics
• CPC Class Codes: A61Q 19/007 Preparations for dry skin
• CPC Class Codes: A61Q 5/006 Antidandruff preparations

Abstract

Dryness of keratin materials, in particular dryness of the skin, and especially disorders associated with dry and/or hyposeborrheic skin are treated by administering to individuals afflicted therewith, thus effective amounts of at least one extract of a non-photosynthetic and non-fruiting filamentous bacterium cultured in a medium which includes at least one non-sulfurous mineral and/or thermal water, e.g., an extract derived from the bacterium Vitreoscilla filiformis, in particular the strain ATCC 15551, cultured in a medium enriched with water from La Roche Posay.

Claims

1. A cosmetic/dermatological regime or regimen for treating the signs associated with dryness of keratin minerals, comprising administering to an individual in need of such treatment, a thus effective amount of at least one extract of a non-photosynthetic and non-fruiting filamentous bacterium cultured in a medium which comprises at least one non-sulfurous mineral and/or thermal water.

2. The cosmetic/dermatological regime or regimen as defined by claim 1, said non-photosynthetic and non-fruiting filamentous bacterium comprising Vitreoscilla filiformis.

3. The cosmetic/dermatological regime or regimen as defined by claim 1, said at least one non-sulfurous mineral and/or thermal water comprising that from La Roche Posay.

4. The cosmetic/dermatological regime or regimen as defined by claim 1, said non-photosynthetic and non-fruiting filamentous bacterium comprising those of the genera Beggiatoa, Vitreoscilla, Flexithrix or Leucothrix.

5. The cosmetic/dermatological regime or regimen as defined by claim 1, said non-photosynthetic and non-fruiting filamentous bacterium comprising:

Vitreoscilla filiformis (ATCC

     15551);

Vitreoscilla beggiatoides (ATCC

     43181);

Beggiatoa alba (ATCC

     33555);

Flexithrix dorotheae (ATCC

     23163);

Leucothrix mucor (ATCC

     25107);

or

Sphaerotilus natans (ATCC

     13338).

6. The cosmetic/dermatological regime or regimen as defined by claim 1, said at least one non-sulfurous mineral and/or thermal water having a total mineral content ranging from 400 to 900 mg/l.

7. The cosmetic/dermatological regime or regimen as defined by claim 1, said at least one non-sulfurous mineral and/or thermal water having a total concentration of carbonates and of bicarbonates of at least 150 mg/l and a concentration of silicon oxide of at least 6 mg/l.

8. The cosmetic/dermatological regime or regimen as defined by claim 1, said at least one non-sulfurous mineral and/or thermal water comprising that from Vittel, from the Vichy basin, from Uriage, from La Bourboule, from Enghien-les-Bains, from Saint-Gervais-les-Bains, from Né

ris-les-Bains, from Allevard-les-Bains, from Digne, from Maiziè

res, water from Neyrac-les-Bains, from Lons-Ie-Saunier, from Eaux-Bonnes, from Rochefort, from Saint Christau, from Les Fumades or from Tercis-les-Bains.

9. The cosmetic/dermatological regime or regimen as defined by claim 6, said at least one non-sulfurous mineral and/or thermal water having a concentration of calcium ions of at least 100 mg/l.

10. The cosmetic/dermatological regime or regimen as defined by claim 1, said at least one extract comprising from 0.001 to 20% by weight of the total weight of a composition comprised thereof.

11. The cosmetic/dermatological regime or regimen as defined by claim 1, said non-photosynthetic and non-fruiting filamentous bacterium having been cultured in a medium comprising autolyzed yeast extract, plant peptone, anhydrous glucose, Heller microelements and calcium chloride.

12. The cosmetic/dermatological regime or regimen as defined by claim 1, said at least one extract comprising Se, Sr and Zn values.

13. The cosmetic/dermatological regime or regimen as defined by claim 1, comprising topically applying said at least one extract onto the affected keratin materials area of such individual.

14. The cosmetic/dermatological regime or regimen as defined by claim 1, including treating a state of dryness of the skin, a squamous state and/or itching and/or tautness associated with dry skin.

18. The cosmetic/dermatological regime or regimen as defined by claim 1, comprising combating the dull and/or lifeless appearance of the skin and/or keratin fibers.

19. The cosmetic/dermatological regime or regimen as defined by claim 1, comprising treating constitutional or acquired, non-pathological dry skin.

20. The cosmetic/dermatological regime or regimen as defined by claim 1, comprising treating constitutional non-pathological dry skin selected from senile skin and common xerosis.

15. A cosmetic/dermatological regime or regimen for treating a skin disorder related to a deficiency in excretion and/or secretion of sebum and/or physiologically restoring a suitable state of hydration of the stratum corneum and/or treating hyposeborrheic dry skin and/or stimulating sebum production, comprising administering to an individual in need of such treatment, a thus effective amount of at least one extract of a non-photosynthetic and non-fruiting filamentous bacterium cultured in a medium which comprises at least one non-sulfurous mineral and/or thermal water.

16. A cosmetic/dermatological regime or regimen for preventing and/or reducing wrinkles associated with dryness of the skin, comprising administering to an individual in need of such treatment, a thus effective amount of at least one extract of a non-photosynthetic and non-fruiting filamentous bacterium cultured in a medium which comprises at least one non-sulfurous mineral and/or thermal water.

17. A cosmetic/dermatological regime or regimen for treating dry keratin fibers and/or improving the comfort of dry skin and/or dry scalp, comprising administering to an individual in need of such treatment, a thus effective amount of at least one extract of a non-photosynthetic and non-fruiting filamentous bacterium cultured in a medium which comprises at least one non-sulfurous mineral and/or thermal water.

21. A cosmetic/dermatological regime or regimen for treating atopic dermatitis, atopic xerosis, seborrheic dermatitis and hyperkeratosis, comprising administering to an individual in need of such treatment, a thus effective amount of at least one extract of a non-photosynthetic and non-fruiting filamentous bacterium cultured in a medium which comprises at least one non-sulfurous mineral and/or thermal water.

22. A cosmetic/dermatological regime or regimen for preventing and/or treating dry keratin materials, dry and/or delicate skin, and/or for treating hyposeborrheic dry skin, and/or for preventing and/or treating itching and/or tautness and/or for stimulating sebum production, and/or for the treatment and/or prevention of skin disorders and/or disorders of the pilosebaceous unit related to a deficiency in excretion and/or secretion of sebum, and/or for preventing and/or treating dry or brittle keratin fibers, and/or for preventing and/or reducing wrinkles associated with dryness of the skin, comprising administering to an individual in need of such treatment, a thus effective amount of at least one extract of a non-photosynthetic and non-fruiting filamentous bacterium cultured in a medium which comprises at least one non-sulfurous mineral and/or thermal water.

23. A cosmetic/dermatological composition useful for treating the signs associated with dryness of keratin materials, comprising at least one extract of a non-photosynthetic and non-fruiting filamentous bacterium cultured in a medium which comprises at least one mineral and/or thermal water and at least one other active agent selected from the group consisting of vitamins B3, B5, B6, B8 C, E or PP, carotenoids, curcuminoids and niacin.

24. A cosmetic/dermatological composition useful for treating the signs associated with dryness of keratin materials, comprising at least one extract of a non-photosynthetic and non-fruiting filamentous bacterium cultured in a medium which comprises at least one mineral and/or thermal water and at least one other active agent selected from the group consisting of desquamating agents;

moisturizing agents;

anti-glycation agents;

anti-inflammatories or calmatives;

agents for stimulating keratinocyte proliferation and/or differentiation;

anti-dandruff agents; and

anti-microbial agents.