IMPLANTABLE ANALYTE SENSOR
First Claim
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1. An implantable analyte sensor for measuring an analyte concentration in a host, the sensor comprising:
- a sensor body substantially formed from a water vapor permeable material; and
electrical components encapsulated within the sensor body, wherein the electrical components comprise RF circuitry and an antenna adapted for RF transmission from the sensor in vivo to a receiver ex vivo, wherein the RF circuitry is spaced a fixed distance from the sensor body so as to support a dielectric constant that enables RF transmission between the sensor in vivo to the receiver ex vivo.
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Abstract
An implantable analyte sensor including a sensing region for measuring the analyte and a non-sensing region for immobilizing the sensor body in the host. The sensor is implanted in a precisely dimensioned pocket to stabilize the analyte sensor in vivo and enable measurement of the concentration of the analyte in the host before and after formation of a foreign body capsule around the sensor. The sensor further provides a transmitter for RF transmission through the sensor body, electronic circuitry, and a power source optimized for long-term use in the miniaturized sensor body.
993 Citations
24 Claims
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1. An implantable analyte sensor for measuring an analyte concentration in a host, the sensor comprising:
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a sensor body substantially formed from a water vapor permeable material; and electrical components encapsulated within the sensor body, wherein the electrical components comprise RF circuitry and an antenna adapted for RF transmission from the sensor in vivo to a receiver ex vivo, wherein the RF circuitry is spaced a fixed distance from the sensor body so as to support a dielectric constant that enables RF transmission between the sensor in vivo to the receiver ex vivo. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. An analyte sensor for RF transmission between the analyte sensor in vivo and a receiver ex vivo, the sensor comprising:
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a sensor body comprising RF circuitry encapsulated within a substantially water vapor permeable body that enables RF transmission therethrough; a sensing region located on an outer surface of the sensor body for measuring an analyte in soft tissue; a biointerface material disposed adjacent to the sensing region that supports vascularized tissue ingrowth for transport of the analyte to the sensing region; and an anchoring material on a non-sensing outer surface of the sensor body that supports tissue ingrowth for immobilization of the sensor body in soft tissue. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A method for manufacturing an analyte sensor, the method comprising:
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providing sensor electronics designed to process signals from the sensor; conformally coating the sensor electronics with a material that has a first water permeability rate; and molding a water vapor permeable material that has a second water permeability rate around the coated sensor electronics to form a substantially seamless sensor body, wherein the second water permeability rate is greater than the first water penetration rate. - View Dependent Claims (19, 20)
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21. An implantable analyte sensor comprising:
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a body comprising a material which is permeable to water vapor, said body further comprising a sensing region for measuring levels of an analyte; and a transmitter within said body for transmitting the measurements obtained by said sensing region, wherein at least a portion of said transmitter is spaced from said body by a material adapted to reduce water from penetrating therein. - View Dependent Claims (22, 23, 24)
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Specification